Abstract
The lack of a surrogate-of-immunity assay presents a major barrier to Streptococcus pyogenes research. Modification of the Lancefield assay to include an antibody digestion step reduced inter-donor variation and permitted detection of the anti-streptococcal activity of intravenous immunoglobulin and convalescent serum, thus facilitating retrospective evaluation of immunity using stored samples.
Original language | English |
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Pages (from-to) | 69-71 |
Number of pages | 3 |
Journal | Journal of microbiological methods |
Volume | 124 |
DOIs | |
Publication status | Published - 24 May 2016 |
Keywords / Materials (for Non-textual outputs)
- Antibodies, Bacterial/blood
- Bacterial Proteins/immunology
- Humans
- Immunoassay/methods
- Streptococcal Infections/blood
- Streptococcus pyogenes/enzymology