Modification of the classical Lancefield assay of group A streptococcal killing to reduce inter-donor variation

Mark Reglinski, Nicola N Lynskey, Shiranee Sriskandan

Research output: Contribution to journalArticlepeer-review

Abstract

The lack of a surrogate-of-immunity assay presents a major barrier to Streptococcus pyogenes research. Modification of the Lancefield assay to include an antibody digestion step reduced inter-donor variation and permitted detection of the anti-streptococcal activity of intravenous immunoglobulin and convalescent serum, thus facilitating retrospective evaluation of immunity using stored samples.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalJournal of microbiological methods
Volume124
DOIs
Publication statusPublished - 24 May 2016

Keywords

  • Antibodies, Bacterial/blood
  • Bacterial Proteins/immunology
  • Humans
  • Immunoassay/methods
  • Streptococcal Infections/blood
  • Streptococcus pyogenes/enzymology

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