Modulating effect of apolipoprotein E polymorphisms on secondary brain insult and outcome after childhood brain trauma

T. Y. M. Lo, P. A. Jones, I. R. Chambers, T. F. Beattie, R. Forsyth, A. D. Mendelow, R. A. Minns

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to determine the relationship between apolipoprotein E (APO E) alleles, the amount of cerebral perfusion pressure (CPP) insult and outcome in children after brain trauma.

In a prospective two-centre case-control study, the APO E genotypes of 65 critically ill children admitted after brain trauma were correlated with age-related CPP insult quantification, conscious state at the time of discharge from intensive care and global outcome at 6 months post-injury. One hundred sixty healthy age- and sex-matched children were genotyped as controls.

The CPP insult level among the e4 carriers with poor outcome was significantly less than the non-e4 carriers (p = 0.03). Homozygotic e3 patients with good recovery did so despite having suffered nearly 26 times more CPP insult than those who were not e3 homzygous (p = 0.02).

Different APO E alleles may potentially affect cerebral ischaemic tolerance differently in children after brain trauma.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
JournalChild's Nervous System
Volume25
Issue number1
DOIs
Publication statusPublished - Jan 2009

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