Modulation of host immunity by helminths : the expanding repertoire of parasite effector molecules

Rick M Maizels, Hermelijin H Smits, Henry McSorley

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules which are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to revolutionise our understanding of parasite adaptation to the host, and to develop possible therapies for immune-mediated disease. In this review we will summarise the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.
Original languageEnglish
Pages (from-to)801-818
JournalImmunity
Volume49
Issue number5
Early online date30 Nov 2018
DOIs
Publication statusE-pub ahead of print - 30 Nov 2018

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