Molecular analysis of trypanosome infections in Algerian camels

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Abstract

Purpose
Surra is an economically important livestock disease in many low- and middle-income countries, including those of Northern Africa. The disease is caused by the biting fly-transmitted subspecies Trypanosoma brucei evansi, which is very closely related to the tsetse-transmitted subspecies T. b. brucei and the sexually transmitted subspecies T. b. equiperdum. At least two phylogenetically distinct groups of T. b. evansi can be distinguished, called type A and type B. These evolved from T. b. brucei independently. The close relationships between the T. brucei subspecies and the multiple evolutionary origins of T. b. evansi pose diagnostic challenges.

Methods
Here we use previously established and newly developed PCR assays based on nuclear and mitochondrial genetic markers to type the causative agent of recent trypanosome infections of camels in Southern Algeria.

Results/conclusion
We confirm that these infections have been caused by T. b. evansi type A. We also report a newly designed PCR assay specific for T. b. evansi type A that we expect will be of diagnostic use for the community.
Original languageEnglish
Number of pages8
JournalActa Parasitologica
Early online date3 Jun 2022
DOIs
Publication statusPublished - 3 Jun 2022

Keywords

  • surra
  • trypanosoma brucei evansi
  • kDNA
  • kinetoplast
  • minicircle

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