Molecular characteristics and clinical behaviour of epithelial ovarian cancers

Robert L. Hollis*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Ovarian carcinoma (OC) is an umbrella term for multiple distinct diseases (histotypes), each with their own developmental origins, clinical behaviour and molecular profile. Accordingly, OC management is progressing away from a one-size-fits all approach, toward more molecularly-driven, histotype-specific management strategies. Our knowledge of driver events in high grade serous OC, the most common histotype, has led to major advances in treatments, including PARP inhibitor use. However, these agents are not suitable for all patients, most notably for many of those with rare OC histotypes. Identification of additional targeted therapeutic strategies will require a detailed understanding of the molecular landscape in each OC histotype. Until recently,
tumour profiling studies in rare histotypes were sparse; however, significant advances have been made over the last decade. In particular, reports of genomic characterisation in endometrioid, clear cell, mucinous and low
grade serous OC have significantly expanded our understanding of mutational events in these tumour types. Nonetheless, substantial knowledge gaps remain. This review summarises our current understanding of each histotype, highlighting recent advances in these unique diseases and outlining immediate research priorities for accelerating progress toward improving patient outcomes
Original languageEnglish
Pages (from-to)216057
JournalCancer letters
Volume555
DOIs
Publication statusPublished - 7 Jan 2023

Keywords / Materials (for Non-textual outputs)

  • ovarian cancer
  • ovarian carcinoma
  • low grade serous ovarian cancer
  • mucinous ovarian cancer
  • clear cell ovarian cancer
  • Endometriod ovarian cancer
  • Ovarian carcinosarcoma
  • Molecular profiling
  • survival
  • Treatment
  • High grade serous ovarian cancer

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