Molecular characteristics of serrated adenomas of the colorectum

E J Sawyer, A Cerar, A M Hanby, P Gorman, M Arends, I C Talbot, I P M Tomlinson

Research output: Contribution to journalArticlepeer-review

Abstract

Serrated adenomas (SAs) of the colorectum combine architectural features of hyperplastic polyps and cytological features of classical adenomas. Molecular studies comparing SAs and classical adenomas suggest that each may be a distinct entity; in particular, it has been proposed that microsatellite instability (MSI) distinguishes SAs from classical adenomas and that SAs and the colorectal cancers arising from them develop along a pathway driven by low level microsatellite instability (MSI-L).
Original languageEnglish
Pages (from-to)200-6
Number of pages7
JournalGut
Volume51
Issue number2
DOIs
Publication statusPublished - Aug 2002

Keywords

  • Adenoma
  • Colorectal Neoplasms
  • Cytoskeletal Proteins
  • Gene Expression Profiling
  • Genes, APC
  • Genes, p53
  • Genes, ras
  • Humans
  • Immunohistochemistry
  • Loss of Heterozygosity
  • Mutation
  • Trans-Activators
  • beta Catenin

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