Molecular dating of human-to-bovid host jumps by Staphylococcus aureus reveals an association with the spread of domestication

Lucy A Weinert; John J Welch; Marc A Suchard; Philippe Lemey; Andrew Rambaut; J Ross Fitzgerald

doi:10.1098/rsbl.2012.0290

Molecular dating of human-to-bovid host jumps by Staphylococcus aureus reveals an association with the spread of domestication

Lucy A Weinert, John J Welch, Marc A Suchard, Philippe Lemey, Andrew Rambaut, J Ross Fitzgerald

Research output: Contribution to journal › Article › peer-review

Abstract

Host species switches by bacterial pathogens leading to new endemic infections are important evolutionary events that are difficult to reconstruct over the long term. We investigated the host switching of Staphylococcus aureus over a long evolutionary timeframe by developing Bayesian phylogenetic methods to account for uncertainty about past host associations and using estimates of evolutionary rates from serially sampled whole-genome data. Results suggest multiple jumps back and forth between human and bovids with the first switch from humans to bovids taking place around 5500 BP, coinciding with the expansion of cattle domestication throughout the Old World. The first switch to poultry is estimated at around 275 BP, long after domestication but still preceding large-scale commercial farming. These results are consistent with a central role for anthropogenic change in the emergence of new endemic diseases.

Original language	English
Pages (from-to)	829-832
Journal	Biology letters
Volume	8
Issue number	5
Early online date	26 May 2012
DOIs	https://doi.org/10.1098/rsbl.2012.0290
Publication status	Published - 2012

Keywords / Materials (for Non-textual outputs)

Bayesian phylogenetics
molecular clocks
bacterial evolution
host switching

Access to Document

10.1098/rsbl.2012.0290

Weinert LA 2012
Copyright 2012 The Royal Society
Final published version, 300 KB

http://rsbl.royalsocietypublishing.org/content/early/2012/05/15/rsbl.2012.0290

Innate immunity and endemic diseases in livestock species
Collie, D. (Principal Investigator), Beard, P. (Co-investigator), Bishop, S. (Co-investigator), Bronsvoort, M. (Co-investigator), Burt, D. (Co-investigator), Fitzgerald, R. (Co-investigator), Freeman, T. (Co-investigator), Gally, D. (Co-investigator), Gill, A. (Co-investigator), Glass, E. (Co-investigator), Hocking, P. (Co-investigator), Hope, J. (Co-investigator), Hume, D. (Co-investigator), Kaiser, P. (Co-investigator), Mabbott, N. (Co-investigator), McLachlan, G. (Co-investigator), Morrison, L. (Co-investigator), Stevens, J. (Co-investigator), Stevens, M. (Co-investigator) & Watson, M. (Co-investigator)
BBSRC
1/04/12 → 31/03/17
Project: Research
VIRAL PHYLOGEOGRAPHY: Evolutionary reconstruction of viral spread in time and space
Rambaut, A. (Principal Investigator)
EU government bodies
1/10/10 → 30/09/15
Project: Research

1 Participation in workshop, seminar, course
1 Membership of external research organisation

NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr (External organisation)
Rambaut, A. (Member)
Sept 2009 → Aug 2015
Activity: Membership types › Membership of external research organisation
NESCENT Working Group meeting on Software for Bayesian Evolutionary Analysis by Sampling Trees
Rambaut, A. (Organiser)
2009 → 2013
Activity: Participating in or organising an event types › Participation in workshop, seminar, course

Cite this

@article{151d1cf6c9724351bff5699628249c30,

title = "Molecular dating of human-to-bovid host jumps by Staphylococcus aureus reveals an association with the spread of domestication",

abstract = "Host species switches by bacterial pathogens leading to new endemic infections are important evolutionary events that are difficult to reconstruct over the long term. We investigated the host switching of Staphylococcus aureus over a long evolutionary timeframe by developing Bayesian phylogenetic methods to account for uncertainty about past host associations and using estimates of evolutionary rates from serially sampled whole-genome data. Results suggest multiple jumps back and forth between human and bovids with the first switch from humans to bovids taking place around 5500 BP, coinciding with the expansion of cattle domestication throughout the Old World. The first switch to poultry is estimated at around 275 BP, long after domestication but still preceding large-scale commercial farming. These results are consistent with a central role for anthropogenic change in the emergence of new endemic diseases.",

keywords = "Bayesian phylogenetics, molecular clocks, bacterial evolution, host switching",

author = "Weinert, {Lucy A} and Welch, {John J} and Suchard, {Marc A} and Philippe Lemey and Andrew Rambaut and Fitzgerald, {J Ross}",

year = "2012",

doi = "10.1098/rsbl.2012.0290",

language = "English",

volume = "8",

pages = "829--832",

journal = "Biology letters",

issn = "1744-9561",

publisher = "The Royal Society",

number = "5",

}

TY - JOUR

T1 - Molecular dating of human-to-bovid host jumps by Staphylococcus aureus reveals an association with the spread of domestication

AU - Weinert, Lucy A

AU - Welch, John J

AU - Suchard, Marc A

AU - Lemey, Philippe

AU - Rambaut, Andrew

AU - Fitzgerald, J Ross

PY - 2012

Y1 - 2012

N2 - Host species switches by bacterial pathogens leading to new endemic infections are important evolutionary events that are difficult to reconstruct over the long term. We investigated the host switching of Staphylococcus aureus over a long evolutionary timeframe by developing Bayesian phylogenetic methods to account for uncertainty about past host associations and using estimates of evolutionary rates from serially sampled whole-genome data. Results suggest multiple jumps back and forth between human and bovids with the first switch from humans to bovids taking place around 5500 BP, coinciding with the expansion of cattle domestication throughout the Old World. The first switch to poultry is estimated at around 275 BP, long after domestication but still preceding large-scale commercial farming. These results are consistent with a central role for anthropogenic change in the emergence of new endemic diseases.

AB - Host species switches by bacterial pathogens leading to new endemic infections are important evolutionary events that are difficult to reconstruct over the long term. We investigated the host switching of Staphylococcus aureus over a long evolutionary timeframe by developing Bayesian phylogenetic methods to account for uncertainty about past host associations and using estimates of evolutionary rates from serially sampled whole-genome data. Results suggest multiple jumps back and forth between human and bovids with the first switch from humans to bovids taking place around 5500 BP, coinciding with the expansion of cattle domestication throughout the Old World. The first switch to poultry is estimated at around 275 BP, long after domestication but still preceding large-scale commercial farming. These results are consistent with a central role for anthropogenic change in the emergence of new endemic diseases.

KW - Bayesian phylogenetics

KW - molecular clocks

KW - bacterial evolution

KW - host switching

U2 - 10.1098/rsbl.2012.0290

DO - 10.1098/rsbl.2012.0290

M3 - Article

C2 - 22628096

SN - 1744-9561

VL - 8

SP - 829

EP - 832

JO - Biology letters

JF - Biology letters

IS - 5

ER -

Molecular dating of human-to-bovid host jumps by Staphylococcus aureus reveals an association with the spread of domestication

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

Innate immunity and endemic diseases in livestock species

VIRAL PHYLOGEOGRAPHY: Evolutionary reconstruction of viral spread in time and space

Activities

NIH, Div Int Epidemiol & Populat Studies, Fogarty Int Ctr (External organisation)

NESCENT Working Group meeting on Software for Bayesian Evolutionary Analysis by Sampling Trees

Cite this