Molecular epidemiology of hepatitis C virus infection amongst intravenous drug users in rural communities

A Majid, R Holmes, U Desselberger, P Simmonds, T A McKee

Research output: Contribution to journalArticlepeer-review

Abstract

The prevalence of hepatitis C virus (HCV) infection amongst a group of intravenous drug users (IVDUs) resident in West Suffolk (East Anglia, England) was investigated and compared with the prevalence of infection with hepatitis B virus (HBV) and human immunodeficiency virus (HIV). In addition, both the level of HCV persistence, as defined by detection of viral RNA, and the HCV genotypes present in this population were determined. It was found that HCV antibodies were present in 59% of those tested; by comparison 22% had antibodies to HBV and 1% antibodies to HIV. HCV RNA was found in 44% of those with HCV antibody. HCV genotype 1 was the most prevalent within this population although both genotypes 2 and 3 were also represented.
Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalJournal of Medical Virology
Volume46
Issue number1
DOIs
Publication statusPublished - May 1995

Keywords

  • Adolescent
  • Adult
  • Base Sequence
  • Genotype
  • Great Britain
  • HIV Antibodies
  • Hepacivirus
  • Hepatitis Antibodies
  • Hepatitis B Antibodies
  • Hepatitis C
  • Hepatitis C Antibodies
  • Humans
  • Middle Aged
  • Molecular Sequence Data
  • Prevalence
  • RNA, Viral
  • Rural Population
  • Seroepidemiologic Studies
  • Serotyping
  • Substance Abuse, Intravenous

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