Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

Barbara Royer; Dinesh C Soares; Paul N Barlow; Ronald E Bontrop; Patrice Roll; Andrée Robaglia-Schlupp; Antoine Blancher; Anthony Levasseur; Pierre Cau; Pierre Pontarotti; Pierre Szepetowski

doi:10.1186/1471-2156-8-72

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

Barbara Royer, Dinesh C Soares, Paul N Barlow, Ronald E Bontrop, Patrice Roll, Andrée Robaglia-Schlupp, Antoine Blancher, Anthony Levasseur, Pierre Cau, Pierre Pontarotti, Pierre Szepetowski

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

The X-linked SRPX2 gene encodes a Sushi Repeat-containing Protein of unknown function and is mutated in two disorders of the Rolandic/Sylvian speech areas. Since it is linked to defects in the functioning and the development of brain areas for speech production, SRPX2 may thus have participated in the adaptive organization of such brain regions. To address this issue, we have examined the recent molecular evolution of the SRPX2 gene.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	BMC Genetics
Volume	8
Issue number	72
DOIs	https://doi.org/10.1186/1471-2156-8-72
Publication status	Published - 2007

Keywords / Materials (for Non-textual outputs)

Amino Acid Sequence
Animals
Brain Diseases
Evolution, Molecular
Female
Frontal Lobe
Humans
Models, Molecular
Nerve Tissue Proteins
Phylogeny
Polymorphism, Single Nucleotide
Primates
Protein Interaction Mapping
Sequence Alignment
Species Specificity
Speech

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10.1186/1471-2156-8-72

BMC Genet 2007Final published version, 442 KB

http://www.biomedcentral.com/1471-2156/8/72

Cite this

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title = "Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas",

abstract = "The X-linked SRPX2 gene encodes a Sushi Repeat-containing Protein of unknown function and is mutated in two disorders of the Rolandic/Sylvian speech areas. Since it is linked to defects in the functioning and the development of brain areas for speech production, SRPX2 may thus have participated in the adaptive organization of such brain regions. To address this issue, we have examined the recent molecular evolution of the SRPX2 gene.",

keywords = "Amino Acid Sequence, Animals, Brain Diseases, Evolution, Molecular, Female, Frontal Lobe, Humans, Models, Molecular, Nerve Tissue Proteins, Phylogeny, Polymorphism, Single Nucleotide, Primates, Protein Interaction Mapping, Sequence Alignment, Species Specificity, Speech",

author = "Barbara Royer and Soares, {Dinesh C} and Barlow, {Paul N} and Bontrop, {Ronald E} and Patrice Roll and Andr{\'e}e Robaglia-Schlupp and Antoine Blancher and Anthony Levasseur and Pierre Cau and Pierre Pontarotti and Pierre Szepetowski",

year = "2007",

doi = "10.1186/1471-2156-8-72",

language = "English",

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publisher = "BioMed Central",

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T1 - Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

AU - Royer, Barbara

AU - Soares, Dinesh C

AU - Barlow, Paul N

AU - Bontrop, Ronald E

AU - Roll, Patrice

AU - Robaglia-Schlupp, Andrée

AU - Blancher, Antoine

AU - Levasseur, Anthony

AU - Cau, Pierre

AU - Pontarotti, Pierre

AU - Szepetowski, Pierre

PY - 2007

Y1 - 2007

N2 - The X-linked SRPX2 gene encodes a Sushi Repeat-containing Protein of unknown function and is mutated in two disorders of the Rolandic/Sylvian speech areas. Since it is linked to defects in the functioning and the development of brain areas for speech production, SRPX2 may thus have participated in the adaptive organization of such brain regions. To address this issue, we have examined the recent molecular evolution of the SRPX2 gene.

AB - The X-linked SRPX2 gene encodes a Sushi Repeat-containing Protein of unknown function and is mutated in two disorders of the Rolandic/Sylvian speech areas. Since it is linked to defects in the functioning and the development of brain areas for speech production, SRPX2 may thus have participated in the adaptive organization of such brain regions. To address this issue, we have examined the recent molecular evolution of the SRPX2 gene.

KW - Amino Acid Sequence

KW - Animals

KW - Brain Diseases

KW - Evolution, Molecular

KW - Female

KW - Frontal Lobe

KW - Humans

KW - Models, Molecular

KW - Nerve Tissue Proteins

KW - Phylogeny

KW - Polymorphism, Single Nucleotide

KW - Primates

KW - Protein Interaction Mapping

KW - Sequence Alignment

KW - Species Specificity

KW - Speech

U2 - 10.1186/1471-2156-8-72

DO - 10.1186/1471-2156-8-72

M3 - Article

C2 - 17942002

VL - 8

SP - 1

EP - 9

JO - BMC Genetics

JF - BMC Genetics

IS - 72

ER -

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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