Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas

Barbara Royer, Dinesh C Soares, Paul N Barlow, Ronald E Bontrop, Patrice Roll, Andrée Robaglia-Schlupp, Antoine Blancher, Anthony Levasseur, Pierre Cau, Pierre Pontarotti, Pierre Szepetowski

Research output: Contribution to journalArticlepeer-review

Abstract

The X-linked SRPX2 gene encodes a Sushi Repeat-containing Protein of unknown function and is mutated in two disorders of the Rolandic/Sylvian speech areas. Since it is linked to defects in the functioning and the development of brain areas for speech production, SRPX2 may thus have participated in the adaptive organization of such brain regions. To address this issue, we have examined the recent molecular evolution of the SRPX2 gene.
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalBMC Genetics
Volume8
Issue number72
DOIs
Publication statusPublished - 2007

Keywords

  • Amino Acid Sequence
  • Animals
  • Brain Diseases
  • Evolution, Molecular
  • Female
  • Frontal Lobe
  • Humans
  • Models, Molecular
  • Nerve Tissue Proteins
  • Phylogeny
  • Polymorphism, Single Nucleotide
  • Primates
  • Protein Interaction Mapping
  • Sequence Alignment
  • Species Specificity
  • Speech

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