Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

Daniel J Antoine; Rosalind E Jenkins; James W Dear; Dominic P Williams; Mitchell R McGill; Matthew R Sharpe; Darren G Craig; Kenneth J Simpson; Hartmut Jaeschke; B Kevin Park

doi:10.1016/j.jhep.2011.12.019

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

Daniel J Antoine, Rosalind E Jenkins, James W Dear, Dominic P Williams, Mitchell R McGill, Matthew R Sharpe, Darren G Craig, Kenneth J Simpson, Hartmut Jaeschke, B Kevin Park

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo. In addition, the caspase-cleaved fragment of K18 (cK18) and hyper-acetylated HMGB1 represent serum indicators of apoptosis and immune cell activation, respectively. The study aim was to assess their mechanistic utility to establish the balance between apoptosis, necrosis, and immune cell activation throughout the time course of clinical APAP hepatotoxicity.

Original language	English
Pages (from-to)	1070-9
Number of pages	10
Journal	Journal of Hepatology
Volume	56
Issue number	5
DOIs	https://doi.org/10.1016/j.jhep.2011.12.019
Publication status	Published - 2012

Access to Document

10.1016/j.jhep.2011.12.019

Cite this

Antoine, D. J., Jenkins, R. E., Dear, J. W., Williams, D. P., McGill, M. R., Sharpe, M. R., Craig, D. G., Simpson, K. J., Jaeschke, H., & Park, B. K. (2012). Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. Journal of Hepatology, 56(5), 1070-9. https://doi.org/10.1016/j.jhep.2011.12.019

@article{9be6c5fd6ce14143907097ee1bacc517,

title = "Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity",

abstract = "Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo. In addition, the caspase-cleaved fragment of K18 (cK18) and hyper-acetylated HMGB1 represent serum indicators of apoptosis and immune cell activation, respectively. The study aim was to assess their mechanistic utility to establish the balance between apoptosis, necrosis, and immune cell activation throughout the time course of clinical APAP hepatotoxicity.",

author = "Antoine, {Daniel J} and Jenkins, {Rosalind E} and Dear, {James W} and Williams, {Dominic P} and McGill, {Mitchell R} and Sharpe, {Matthew R} and Craig, {Darren G} and Simpson, {Kenneth J} and Hartmut Jaeschke and Park, {B Kevin}",

year = "2012",

doi = "10.1016/j.jhep.2011.12.019",

language = "English",

volume = "56",

pages = "1070--9",

journal = "Journal of Hepatology",

issn = "0168-8278",

publisher = "Elsevier",

number = "5",

}

Antoine, DJ, Jenkins, RE, Dear, JW, Williams, DP, McGill, MR, Sharpe, MR, Craig, DG, Simpson, KJ, Jaeschke, H & Park, BK 2012, 'Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity', Journal of Hepatology, vol. 56, no. 5, pp. 1070-9. https://doi.org/10.1016/j.jhep.2011.12.019

TY - JOUR

T1 - Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

AU - Antoine, Daniel J

AU - Jenkins, Rosalind E

AU - Dear, James W

AU - Williams, Dominic P

AU - McGill, Mitchell R

AU - Sharpe, Matthew R

AU - Craig, Darren G

AU - Simpson, Kenneth J

AU - Jaeschke, Hartmut

AU - Park, B Kevin

PY - 2012

Y1 - 2012

N2 - Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo. In addition, the caspase-cleaved fragment of K18 (cK18) and hyper-acetylated HMGB1 represent serum indicators of apoptosis and immune cell activation, respectively. The study aim was to assess their mechanistic utility to establish the balance between apoptosis, necrosis, and immune cell activation throughout the time course of clinical APAP hepatotoxicity.

AB - Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo. In addition, the caspase-cleaved fragment of K18 (cK18) and hyper-acetylated HMGB1 represent serum indicators of apoptosis and immune cell activation, respectively. The study aim was to assess their mechanistic utility to establish the balance between apoptosis, necrosis, and immune cell activation throughout the time course of clinical APAP hepatotoxicity.

U2 - 10.1016/j.jhep.2011.12.019

DO - 10.1016/j.jhep.2011.12.019

M3 - Article

C2 - 22266604

SN - 0168-8278

VL - 56

SP - 1070

EP - 1079

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 5

ER -

Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

Abstract / Description of output

Access to Document

Fingerprint

Cite this