Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity

Daniel J Antoine, Rosalind E Jenkins, James W Dear, Dominic P Williams, Mitchell R McGill, Matthew R Sharpe, Darren G Craig, Kenneth J Simpson, Hartmut Jaeschke, B Kevin Park

Research output: Contribution to journalArticlepeer-review

Abstract

Full length keratin-18 (FL-K18) and High Mobility Group Box-1 (HMGB1) represent circulating indicators of necrosis during acetaminophen (APAP) hepatotoxicity in vivo. In addition, the caspase-cleaved fragment of K18 (cK18) and hyper-acetylated HMGB1 represent serum indicators of apoptosis and immune cell activation, respectively. The study aim was to assess their mechanistic utility to establish the balance between apoptosis, necrosis, and immune cell activation throughout the time course of clinical APAP hepatotoxicity.
Original languageEnglish
Pages (from-to)1070-9
Number of pages10
JournalJournal of Hepatology
Volume56
Issue number5
DOIs
Publication statusPublished - 2012

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