Molecular Insights into RNA Modifications and their Role in Shaping Immune Responses and Tumor Microenvironments

Ashiq Ali; Tehreem Ajmal; Aisha Khatoon; Kaynaat Akbar; Urooj Irshad; Bilal Murtaza; Ziyi Ji; Abdullah Ali; Qaisar Tanveer; Zhongjing Su

doi:10.2174/0115665232335322241205063758

Molecular Insights into RNA Modifications and their Role in Shaping Immune Responses and Tumor Microenvironments

Ashiq Ali, Tehreem Ajmal, Aisha Khatoon, Kaynaat Akbar, Urooj Irshad, Bilal Murtaza, Ziyi Ji, Abdullah Ali, Qaisar Tanveer, Zhongjing Su

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Review article › peer-review

Abstract

RNA modifications play crucial roles in immune system development and function, with dynamic changes essential for diverse cellular processes. Innovative profiling technologies are invaluable for understanding the significance of these modifications in immune cells, both in healthy and diseased states. This review explores the utility of such technologies in uncovering the functions of RNA modifications and their impact on immune responses. Additionally, it delves into the mechanisms through which aberrant RNA modifications influence the tumor microenvironments immune milieu. Despite significant progress, several outstanding research questions remain, highlighting the need for further investigation into the molecular mechanisms underlying RNA modification's effects on immune function in various contexts.

Original language	English
Pages (from-to)	627-645
Number of pages	43
Journal	Current gene therapy
Volume	25
Issue number	5
Early online date	21 Jan 2025
DOIs	https://doi.org/10.2174/0115665232335322241205063758
Publication status	E-pub ahead of print - 21 Jan 2025

Keywords / Materials (for Non-textual outputs)

RNA modifications
immune responses
immune system development
tumor microenvironment

Access to Document

10.2174/0115665232335322241205063758

BMS-CGT-2024-90Accepted author manuscript, 0.99 MBLicence: Creative Commons: Attribution (CC-BY)

Cite this

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title = "Molecular Insights into RNA Modifications and their Role in Shaping Immune Responses and Tumor Microenvironments",

abstract = "RNA modifications play crucial roles in immune system development and function, with dynamic changes essential for diverse cellular processes. Innovative profiling technologies are invaluable for understanding the significance of these modifications in immune cells, both in healthy and diseased states. This review explores the utility of such technologies in uncovering the functions of RNA modifications and their impact on immune responses. Additionally, it delves into the mechanisms through which aberrant RNA modifications influence the tumor microenvironments immune milieu. Despite significant progress, several outstanding research questions remain, highlighting the need for further investigation into the molecular mechanisms underlying RNA modification's effects on immune function in various contexts.",

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AU - Ali, Ashiq

AU - Ajmal, Tehreem

AU - Khatoon, Aisha

AU - Akbar, Kaynaat

AU - Irshad, Urooj

AU - Murtaza, Bilal

AU - Ji, Ziyi

AU - Ali, Abdullah

AU - Tanveer, Qaisar

AU - Su, Zhongjing

PY - 2025/1/21

Y1 - 2025/1/21

N2 - RNA modifications play crucial roles in immune system development and function, with dynamic changes essential for diverse cellular processes. Innovative profiling technologies are invaluable for understanding the significance of these modifications in immune cells, both in healthy and diseased states. This review explores the utility of such technologies in uncovering the functions of RNA modifications and their impact on immune responses. Additionally, it delves into the mechanisms through which aberrant RNA modifications influence the tumor microenvironments immune milieu. Despite significant progress, several outstanding research questions remain, highlighting the need for further investigation into the molecular mechanisms underlying RNA modification's effects on immune function in various contexts.

AB - RNA modifications play crucial roles in immune system development and function, with dynamic changes essential for diverse cellular processes. Innovative profiling technologies are invaluable for understanding the significance of these modifications in immune cells, both in healthy and diseased states. This review explores the utility of such technologies in uncovering the functions of RNA modifications and their impact on immune responses. Additionally, it delves into the mechanisms through which aberrant RNA modifications influence the tumor microenvironments immune milieu. Despite significant progress, several outstanding research questions remain, highlighting the need for further investigation into the molecular mechanisms underlying RNA modification's effects on immune function in various contexts.

KW - RNA modifications

KW - immune responses

KW - immune system development

KW - tumor microenvironment

U2 - 10.2174/0115665232335322241205063758

DO - 10.2174/0115665232335322241205063758

M3 - Review article

C2 - 39844555

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VL - 25

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EP - 645

JO - Current gene therapy

JF - Current gene therapy

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ER -

Molecular Insights into RNA Modifications and their Role in Shaping Immune Responses and Tumor Microenvironments

Abstract

Keywords / Materials (for Non-textual outputs)

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