Molecular Interaction of Bone Marrow Adipose Tissue with Energy Metabolism

Karla J. Suchacki; William P. Cawthorn

doi:10.1007/s40610-018-0096-8

Molecular Interaction of Bone Marrow Adipose Tissue with Energy Metabolism

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Purpose of Review: The last decade has seen a resurgence in the study of bone marrow adipose tissue (BMAT) across diverse fields such as metabolism, haematopoiesis, skeletal biology and cancer. Herein, we review the most recent developments of BMAT research in both humans and rodents, including the distinct nature of BMAT; the autocrine, paracrine and endocrine interactions between BMAT and various tissues, both in physiological and pathological scenarios; how these interactions might impact energy metabolism; and the most recent technological advances to quantify BMAT.

Recent Findings: Though still dwarfed by research into white and brown adipose tissues, BMAT is now recognised as endocrine organ and is attracting increasing attention from biomedical researchers around the globe.

Summary: We are beginning to learn the importance of BMAT both within and beyond the bone, allowing us to better appreciate the role of BMAT in normal physiology and disease.

Original language	English
Pages (from-to)	41-49
Number of pages	9
Journal	Current Molecular Biology Reports
Volume	4
Issue number	2
Early online date	28 May 2018
DOIs	https://doi.org/10.1007/s40610-018-0096-8
Publication status	Published - 1 Jun 2018

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Bone marrow adipose tissue as a novel regulator of metabolic homeostasis
Cawthorn, W.
MRC
1/08/15 → 30/06/22
Project: Research

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title = "Molecular Interaction of Bone Marrow Adipose Tissue with Energy Metabolism",

abstract = "Purpose of Review: The last decade has seen a resurgence in the study of bone marrow adipose tissue (BMAT) across diverse fields such as metabolism, haematopoiesis, skeletal biology and cancer. Herein, we review the most recent developments of BMAT research in both humans and rodents, including the distinct nature of BMAT; the autocrine, paracrine and endocrine interactions between BMAT and various tissues, both in physiological and pathological scenarios; how these interactions might impact energy metabolism; and the most recent technological advances to quantify BMAT.Recent Findings: Though still dwarfed by research into white and brown adipose tissues, BMAT is now recognised as endocrine organ and is attracting increasing attention from biomedical researchers around the globe.Summary: We are beginning to learn the importance of BMAT both within and beyond the bone, allowing us to better appreciate the role of BMAT in normal physiology and disease.",

author = "Suchacki, {Karla J.} and Cawthorn, {William P.}",

year = "2018",

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doi = "10.1007/s40610-018-0096-8",

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journal = "Current Molecular Biology Reports",

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T1 - Molecular Interaction of Bone Marrow Adipose Tissue with Energy Metabolism

AU - Suchacki, Karla J.

AU - Cawthorn, William P.

PY - 2018/6/1

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N2 - Purpose of Review: The last decade has seen a resurgence in the study of bone marrow adipose tissue (BMAT) across diverse fields such as metabolism, haematopoiesis, skeletal biology and cancer. Herein, we review the most recent developments of BMAT research in both humans and rodents, including the distinct nature of BMAT; the autocrine, paracrine and endocrine interactions between BMAT and various tissues, both in physiological and pathological scenarios; how these interactions might impact energy metabolism; and the most recent technological advances to quantify BMAT.Recent Findings: Though still dwarfed by research into white and brown adipose tissues, BMAT is now recognised as endocrine organ and is attracting increasing attention from biomedical researchers around the globe.Summary: We are beginning to learn the importance of BMAT both within and beyond the bone, allowing us to better appreciate the role of BMAT in normal physiology and disease.

AB - Purpose of Review: The last decade has seen a resurgence in the study of bone marrow adipose tissue (BMAT) across diverse fields such as metabolism, haematopoiesis, skeletal biology and cancer. Herein, we review the most recent developments of BMAT research in both humans and rodents, including the distinct nature of BMAT; the autocrine, paracrine and endocrine interactions between BMAT and various tissues, both in physiological and pathological scenarios; how these interactions might impact energy metabolism; and the most recent technological advances to quantify BMAT.Recent Findings: Though still dwarfed by research into white and brown adipose tissues, BMAT is now recognised as endocrine organ and is attracting increasing attention from biomedical researchers around the globe.Summary: We are beginning to learn the importance of BMAT both within and beyond the bone, allowing us to better appreciate the role of BMAT in normal physiology and disease.

U2 - 10.1007/s40610-018-0096-8

DO - 10.1007/s40610-018-0096-8

M3 - Review article

SN - 2198-6428

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SP - 41

EP - 49

JO - Current Molecular Biology Reports

JF - Current Molecular Biology Reports

IS - 2

ER -

Molecular Interaction of Bone Marrow Adipose Tissue with Energy Metabolism

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Bone marrow adipose tissue as a novel regulator of metabolic homeostasis

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