Molecular mechanisms of liver metastasis

Kenji Kawada; Suguru Hasegawa; Teppei Murakami; Yoshiro Itatani; Hisahiro Hosogi; Masahiro Sonoshita; Takanori Kitamura; Teruaki Fujishita; Masayoshi Iwamoto; Takuya Matsumoto; Ryo Matsusue; Koya Hida; Gaku Akiyama; Kae Okoshi; Masahiro Yamada; Junichiro Kawamura; Makoto Mark Taketo; Yoshiharu Sakai

doi:10.1007/s10147-011-0307-2

Molecular mechanisms of liver metastasis

Kenji Kawada^*, Suguru Hasegawa, Teppei Murakami, Yoshiro Itatani, Hisahiro Hosogi, Masahiro Sonoshita, Takanori Kitamura, Teruaki Fujishita, Masayoshi Iwamoto, Takuya Matsumoto, Ryo Matsusue, Koya Hida, Gaku Akiyama, Kae Okoshi, Masahiro Yamada, Junichiro Kawamura, Makoto Mark Taketo, Yoshiharu Sakai

^*Corresponding author for this work

Deanery of Clinical Sciences

Research output: Contribution to journal › Review article › peer-review

Abstract

Colorectal cancer is the second most common cancer, and is the third leading cause of cancer-related death in Japan. The majority of these deaths is attributable to liver metastasis. Recent studies have provided increasing evidence that the chemokine-chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrowderived cells) to indirectly facilitate tumor invasion and metastasis. Here, we discuss recent preclinical and clinical data supporting the view that chemokine pathways are potential therapeutic targets for liver metastasis of colorectal cancer.

Original language	English
Pages (from-to)	464-472
Number of pages	9
Journal	International Journal of Clinical Oncology
Volume	16
Issue number	5
DOIs	https://doi.org/10.1007/s10147-011-0307-2
Publication status	Published - Oct 2011

Keywords / Materials (for Non-textual outputs)

Chemokine
Colorectal cancer
Liver metastasis

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10.1007/s10147-011-0307-2

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Kawada, K., Hasegawa, S., Murakami, T., Itatani, Y., Hosogi, H., Sonoshita, M., Kitamura, T., Fujishita, T., Iwamoto, M., Matsumoto, T., Matsusue, R., Hida, K., Akiyama, G., Okoshi, K., Yamada, M., Kawamura, J., Taketo, M. M., & Sakai, Y. (2011). Molecular mechanisms of liver metastasis. International Journal of Clinical Oncology, 16(5), 464-472. https://doi.org/10.1007/s10147-011-0307-2

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title = "Molecular mechanisms of liver metastasis",

abstract = "Colorectal cancer is the second most common cancer, and is the third leading cause of cancer-related death in Japan. The majority of these deaths is attributable to liver metastasis. Recent studies have provided increasing evidence that the chemokine-chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrowderived cells) to indirectly facilitate tumor invasion and metastasis. Here, we discuss recent preclinical and clinical data supporting the view that chemokine pathways are potential therapeutic targets for liver metastasis of colorectal cancer.",

keywords = "Chemokine, Colorectal cancer, Liver metastasis",

author = "Kenji Kawada and Suguru Hasegawa and Teppei Murakami and Yoshiro Itatani and Hisahiro Hosogi and Masahiro Sonoshita and Takanori Kitamura and Teruaki Fujishita and Masayoshi Iwamoto and Takuya Matsumoto and Ryo Matsusue and Koya Hida and Gaku Akiyama and Kae Okoshi and Masahiro Yamada and Junichiro Kawamura and Taketo, {Makoto Mark} and Yoshiharu Sakai",

year = "2011",

month = oct,

doi = "10.1007/s10147-011-0307-2",

language = "English",

volume = "16",

pages = "464--472",

journal = "International Journal of Clinical Oncology",

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Kawada, K, Hasegawa, S, Murakami, T, Itatani, Y, Hosogi, H, Sonoshita, M, Kitamura, T, Fujishita, T, Iwamoto, M, Matsumoto, T, Matsusue, R, Hida, K, Akiyama, G, Okoshi, K, Yamada, M, Kawamura, J, Taketo, MM & Sakai, Y 2011, 'Molecular mechanisms of liver metastasis', International Journal of Clinical Oncology, vol. 16, no. 5, pp. 464-472. https://doi.org/10.1007/s10147-011-0307-2

TY - JOUR

T1 - Molecular mechanisms of liver metastasis

AU - Kawada, Kenji

AU - Hasegawa, Suguru

AU - Murakami, Teppei

AU - Itatani, Yoshiro

AU - Hosogi, Hisahiro

AU - Sonoshita, Masahiro

AU - Kitamura, Takanori

AU - Fujishita, Teruaki

AU - Iwamoto, Masayoshi

AU - Matsumoto, Takuya

AU - Matsusue, Ryo

AU - Hida, Koya

AU - Akiyama, Gaku

AU - Okoshi, Kae

AU - Yamada, Masahiro

AU - Kawamura, Junichiro

AU - Taketo, Makoto Mark

AU - Sakai, Yoshiharu

PY - 2011/10

Y1 - 2011/10

N2 - Colorectal cancer is the second most common cancer, and is the third leading cause of cancer-related death in Japan. The majority of these deaths is attributable to liver metastasis. Recent studies have provided increasing evidence that the chemokine-chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrowderived cells) to indirectly facilitate tumor invasion and metastasis. Here, we discuss recent preclinical and clinical data supporting the view that chemokine pathways are potential therapeutic targets for liver metastasis of colorectal cancer.

AB - Colorectal cancer is the second most common cancer, and is the third leading cause of cancer-related death in Japan. The majority of these deaths is attributable to liver metastasis. Recent studies have provided increasing evidence that the chemokine-chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrowderived cells) to indirectly facilitate tumor invasion and metastasis. Here, we discuss recent preclinical and clinical data supporting the view that chemokine pathways are potential therapeutic targets for liver metastasis of colorectal cancer.

KW - Chemokine

KW - Colorectal cancer

KW - Liver metastasis

UR - http://www.scopus.com/inward/record.url?scp=84857075196&partnerID=8YFLogxK

U2 - 10.1007/s10147-011-0307-2

DO - 10.1007/s10147-011-0307-2

M3 - Review article

C2 - 21847533

AN - SCOPUS:84857075196

SN - 1341-9625

VL - 16

SP - 464

EP - 472

JO - International Journal of Clinical Oncology

JF - International Journal of Clinical Oncology

IS - 5

ER -

Molecular mechanisms of liver metastasis

Abstract

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