Molecular mechanisms of liver metastasis

Kenji Kawada*, Suguru Hasegawa, Teppei Murakami, Yoshiro Itatani, Hisahiro Hosogi, Masahiro Sonoshita, Takanori Kitamura, Teruaki Fujishita, Masayoshi Iwamoto, Takuya Matsumoto, Ryo Matsusue, Koya Hida, Gaku Akiyama, Kae Okoshi, Masahiro Yamada, Junichiro Kawamura, Makoto Mark Taketo, Yoshiharu Sakai

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Colorectal cancer is the second most common cancer, and is the third leading cause of cancer-related death in Japan. The majority of these deaths is attributable to liver metastasis. Recent studies have provided increasing evidence that the chemokine-chemokine receptor system is a potential mechanism of tumor metastasis via multiple complementary actions: (a) by promoting cancer cell migration, invasion, survival and angiogenesis; and (b) by recruiting distal stromal cells (i.e., myeloid bone marrowderived cells) to indirectly facilitate tumor invasion and metastasis. Here, we discuss recent preclinical and clinical data supporting the view that chemokine pathways are potential therapeutic targets for liver metastasis of colorectal cancer.

Original languageEnglish
Pages (from-to)464-472
Number of pages9
JournalInternational Journal of Clinical Oncology
Issue number5
Publication statusPublished - Oct 2011

Keywords / Materials (for Non-textual outputs)

  • Chemokine
  • Colorectal cancer
  • Liver metastasis


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