Molecular model of prion transmission to humans

Michael Jones; D. Wight; R. Barron; M. Jeffrey; J. Manson; C. Prowse; J. W. Ironside; M. W. Head

doi:10.3201/eid1512.090194

Molecular model of prion transmission to humans

Michael Jones, D. Wight, R. Barron, M. Jeffrey, J. Manson, C. Prowse, J. W. Ironside, M. W. Head

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Abstract

To assess interspecies barriers to transmission of transmissible spongiform encephalopathies (TSEs), we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.

Original language	English
Pages (from-to)	2013-6
Number of pages	4
Journal	Emerging Infectious Diseases
Volume	15
Issue number	12
DOIs	https://doi.org/10.3201/eid1512.090194
Publication status	Published - Dec 2009

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10.3201/eid1512.090194

Molecular model of prion transmission to humans
Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 15, No. 12, December 2009
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title = "Molecular model of prion transmission to humans",

abstract = "To assess interspecies barriers to transmission of transmissible spongiform encephalopathies (TSEs), we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.",

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AU - Jones, Michael

AU - Wight, D.

AU - Barron, R.

AU - Jeffrey, M.

AU - Manson, J.

AU - Prowse, C.

AU - Ironside, J. W.

AU - Head, M. W.

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AB - To assess interspecies barriers to transmission of transmissible spongiform encephalopathies (TSEs), we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.

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EP - 2016

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

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Molecular model of prion transmission to humans

Abstract

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