Molecular response to aromatase inhibitor treatment in primary breast cancer

Alan Mackay, Ander Urruticoechea, J Michael Dixon, Tim Dexter, Kerry Fenwick, Alan Ashworth, Suzanne Drury, Alexey Larionov, Oliver Young, Sharon White, William R Miller, Dean B Evans, Mitch Dowsett

Research output: Contribution to journalArticlepeer-review

Abstract

Aromatase inhibitors such as anastrozole and letrozole are highly effective suppressants of estrogen synthesis in postmenopausal women and are the most effective endocrine treatments for hormone receptor positive breast cancer in such women. Little is known of the molecular effects of these agents on human breast carcinomas in vivo.
Original languageEnglish
Pages (from-to)R37
JournalBreast Cancer Research
Volume9
Issue number3
DOIs
Publication statusPublished - 2007

Keywords

  • Antineoplastic Agents, Hormonal
  • Aromatase Inhibitors
  • Breast Neoplasms
  • Combined Modality Therapy
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Nitriles
  • Polymerase Chain Reaction
  • Postmenopause
  • Receptors, Estrogen
  • Triazoles
  • Up-Regulation

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