Molecular subclasses of clear cell ovarian carcinoma and their impact on disease behavior and outcomes

Kelly L. Bolton; Denise Chen; Rosario I. Corona De La Fuente; Zhuxuan Fu; Rajmohan Murali; Martin K�bel; Yanis Tazi; Julie M. Cunningham; Irenaeus C.c. Chan; Brian J. Wiley; Lea A. Moukarzel; Stacey J. Winham; Sebastian M. Armasu; Jenny Lester; Esther Elishaev; Angela Laslavic; Catherine J. Kennedy; Anna Piskorz; Magdalena Sekowska; Alison H. Brand; Yoke-eng Chiew; Paul Pharoah; Kevin M. Elias; Ronny Drapkin; Michael Churchman; Charlie Gourley; Anna Defazio; Beth Karlan; James D. Brenton; Britta Weigelt; Michael S. Anglesio; David Huntsman; Simon A. Gayther; Jason Konner; Francesmary Modugno; Kate Lawrenson; Ellen L. Goode; Elli Papaemmanuil

doi:10.1158/1078-0432.CCR-21-3817

Molecular subclasses of clear cell ovarian carcinoma and their impact on disease behavior and outcomes

Kelly L. Bolton, Denise Chen, Rosario I. Corona De La Fuente, Zhuxuan Fu, Rajmohan Murali, Martin K�bel, Yanis Tazi, Julie M. Cunningham, Irenaeus C.c. Chan, Brian J. Wiley, Lea A. Moukarzel, Stacey J. Winham, Sebastian M. Armasu, Jenny Lester, Esther Elishaev, Angela Laslavic, Catherine J. Kennedy, Anna Piskorz, Magdalena Sekowska, Alison H. BrandYoke-eng Chiew, Paul Pharoah, Kevin M. Elias, Ronny Drapkin, Michael Churchman, Charlie Gourley, Anna Defazio, Beth Karlan, James D. Brenton, Britta Weigelt, Michael S. Anglesio, David Huntsman, Simon A. Gayther, Jason Konner, Francesmary Modugno, Kate Lawrenson, Ellen L. Goode, Elli Papaemmanuil

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Clinical Cancer Research
DOIs	https://doi.org/10.1158/1078-0432.CCR-21-3817
Publication status	Published - 11 Jul 2022

Access to Document

10.1158/1078-0432.CCR-21-3817

ccr-21-3817
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License . https://doi.org/10.1158/1078-0432.CCR-21-3817
Accepted author manuscript, 653 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

https://aacrjournals.org/clincancerres/article/doi/10.1158/1078-0432.CCR-21-3817/706955/Molecular-subclasses-of-clear-cell-ovarian

Cite this

Bolton, K. L., Chen, D., Corona De La Fuente, R. I., Fu, Z., Murali, R., K�bel, M., Tazi, Y., Cunningham, J. M., Chan, I. C. C., Wiley, B. J., Moukarzel, L. A., Winham, S. J., Armasu, S. M., Lester, J., Elishaev, E., Laslavic, A., Kennedy, C. J., Piskorz, A., Sekowska, M., ... Papaemmanuil, E. (2022). Molecular subclasses of clear cell ovarian carcinoma and their impact on disease behavior and outcomes. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-3817

@article{629ac879dc75493885044162980318d0,

title = "Molecular subclasses of clear cell ovarian carcinoma and their impact on disease behavior and outcomes",

author = "Bolton, {Kelly L.} and Denise Chen and {Corona De La Fuente}, {Rosario I.} and Zhuxuan Fu and Rajmohan Murali and Martin K�bel and Yanis Tazi and Cunningham, {Julie M.} and Chan, {Irenaeus C.c.} and Wiley, {Brian J.} and Moukarzel, {Lea A.} and Winham, {Stacey J.} and Armasu, {Sebastian M.} and Jenny Lester and Esther Elishaev and Angela Laslavic and Kennedy, {Catherine J.} and Anna Piskorz and Magdalena Sekowska and Brand, {Alison H.} and Yoke-eng Chiew and Paul Pharoah and Elias, {Kevin M.} and Ronny Drapkin and Michael Churchman and Charlie Gourley and Anna Defazio and Beth Karlan and Brenton, {James D.} and Britta Weigelt and Anglesio, {Michael S.} and David Huntsman and Gayther, {Simon A.} and Jason Konner and Francesmary Modugno and Kate Lawrenson and Goode, {Ellen L.} and Elli Papaemmanuil",

note = "Funding Information: Research reported in this publication was supported in part by a Cancer Center Support Grant of the NIH/NCI (Grant No. P30CA008748, MSK) and the Cycle for Funding Information: Research reported in this publication was supported in part by a Cancer Center Support Grant of the NIH/NCI (Grant No. P30CA008748, MSK) and the Cycle for Survival including the Fatma Fund. B. Weigelt is funded in part by Breast Cancer Research Foundation and NIH/NCI (P50 CA247749 01) grants. K.L. Bolton is funded by the Damon Runyon Cancer Research Foundation, the American Society of Hematology, the Evans MDS Foundation and the NCI (Grant 5K08CA241318). Additional support was provided by R21CA222867, R01CA248288, P30CA015083, and P50CA136393. M.S. Anglesio was funded through a Michael Smith Health Research BC Scholar Program award and the Janet D. Cottrelle Foundation Scholars Program (managed by the BC Cancer Foundation). This study used resources provided by the Canadian Ovarian Cancer Research Consortium{\textquoteright}s COEUR biobank funded by the Terry Fox Research Institute and managed and supervised by the Centre hospitalier de l{\textquoteright}Universit{\'e} de Montr{\'e}al. The Consortium acknowledges contributions of its COEUR biobank from Institutions across Canada (for a full list see https://www.tfri.ca/coeur). This work was supported by the Westmead Hospital Department of Gynaecological Oncology, Sydney Australia. The Gynaecological Oncology Biobank at Westmead (GynBiobank), a member of the Australasian Biospecimen Network-Oncology group, was funded by the National Health and Medical Research Council of Australia (Enabling Grants ID 310670 & ID 628903) and the Cancer Institute NSW (Grants 12/RIG/1–17 & 15/RIG/1–16). The Westmead GynBiobank acknowledges financial support from the Sydney West Translational Cancer Research Centre, funded by the Cancer Institute NSW. A. Piskorz, M. Sekowska, and J.D. Brenton were supported by Cancer Research UK grant 22905. Additional support was also provided by the National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre (BRC-1215–20014). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. Publisher Copyright: {\textcopyright}2022 The Authors; Published by the American Association for Cancer Research.",

year = "2022",

month = jul,

day = "11",

doi = "10.1158/1078-0432.CCR-21-3817",

language = "English",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

}

Bolton, KL, Chen, D, Corona De La Fuente, RI, Fu, Z, Murali, R, K�bel, M, Tazi, Y, Cunningham, JM, Chan, ICC, Wiley, BJ, Moukarzel, LA, Winham, SJ, Armasu, SM, Lester, J, Elishaev, E, Laslavic, A, Kennedy, CJ, Piskorz, A, Sekowska, M, Brand, AH, Chiew, Y, Pharoah, P, Elias, KM, Drapkin, R, Churchman, M , Gourley, C, Defazio, A, Karlan, B, Brenton, JD, Weigelt, B, Anglesio, MS, Huntsman, D, Gayther, SA, Konner, J, Modugno, F, Lawrenson, K, Goode, EL & Papaemmanuil, E 2022, 'Molecular subclasses of clear cell ovarian carcinoma and their impact on disease behavior and outcomes', Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-3817

TY - JOUR

T1 - Molecular subclasses of clear cell ovarian carcinoma and their impact on disease behavior and outcomes

AU - Bolton, Kelly L.

AU - Chen, Denise

AU - Corona De La Fuente, Rosario I.

AU - Fu, Zhuxuan

AU - Murali, Rajmohan

AU - K�bel, Martin

AU - Tazi, Yanis

AU - Cunningham, Julie M.

AU - Chan, Irenaeus C.c.

AU - Wiley, Brian J.

AU - Moukarzel, Lea A.

AU - Winham, Stacey J.

AU - Armasu, Sebastian M.

AU - Lester, Jenny

AU - Elishaev, Esther

AU - Laslavic, Angela

AU - Kennedy, Catherine J.

AU - Piskorz, Anna

AU - Sekowska, Magdalena

AU - Brand, Alison H.

AU - Chiew, Yoke-eng

AU - Pharoah, Paul

AU - Elias, Kevin M.

AU - Drapkin, Ronny

AU - Churchman, Michael

AU - Gourley, Charlie

AU - Defazio, Anna

AU - Karlan, Beth

AU - Brenton, James D.

AU - Weigelt, Britta

AU - Anglesio, Michael S.

AU - Huntsman, David

AU - Gayther, Simon A.

AU - Konner, Jason

AU - Modugno, Francesmary

AU - Lawrenson, Kate

AU - Goode, Ellen L.

AU - Papaemmanuil, Elli

N1 - Funding Information: Research reported in this publication was supported in part by a Cancer Center Support Grant of the NIH/NCI (Grant No. P30CA008748, MSK) and the Cycle for Funding Information: Research reported in this publication was supported in part by a Cancer Center Support Grant of the NIH/NCI (Grant No. P30CA008748, MSK) and the Cycle for Survival including the Fatma Fund. B. Weigelt is funded in part by Breast Cancer Research Foundation and NIH/NCI (P50 CA247749 01) grants. K.L. Bolton is funded by the Damon Runyon Cancer Research Foundation, the American Society of Hematology, the Evans MDS Foundation and the NCI (Grant 5K08CA241318). Additional support was provided by R21CA222867, R01CA248288, P30CA015083, and P50CA136393. M.S. Anglesio was funded through a Michael Smith Health Research BC Scholar Program award and the Janet D. Cottrelle Foundation Scholars Program (managed by the BC Cancer Foundation). This study used resources provided by the Canadian Ovarian Cancer Research Consortium’s COEUR biobank funded by the Terry Fox Research Institute and managed and supervised by the Centre hospitalier de l’Université de Montréal. The Consortium acknowledges contributions of its COEUR biobank from Institutions across Canada (for a full list see https://www.tfri.ca/coeur). This work was supported by the Westmead Hospital Department of Gynaecological Oncology, Sydney Australia. The Gynaecological Oncology Biobank at Westmead (GynBiobank), a member of the Australasian Biospecimen Network-Oncology group, was funded by the National Health and Medical Research Council of Australia (Enabling Grants ID 310670 & ID 628903) and the Cancer Institute NSW (Grants 12/RIG/1–17 & 15/RIG/1–16). The Westmead GynBiobank acknowledges financial support from the Sydney West Translational Cancer Research Centre, funded by the Cancer Institute NSW. A. Piskorz, M. Sekowska, and J.D. Brenton were supported by Cancer Research UK grant 22905. Additional support was also provided by the National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre (BRC-1215–20014). The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. Publisher Copyright: ©2022 The Authors; Published by the American Association for Cancer Research.

PY - 2022/7/11

Y1 - 2022/7/11

U2 - 10.1158/1078-0432.CCR-21-3817

DO - 10.1158/1078-0432.CCR-21-3817

M3 - Article

SN - 1078-0432

JO - Clinical Cancer Research

JF - Clinical Cancer Research

ER -