Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status

Stylianos Bournazos, Jillian Rennie, Simon P Hart, Keith A A Fox, Ian Dransfield

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the mechanism of platelet binding to polymorphonuclear leukocytes, monocytes, and monocyte subsets and investigated the potential functional consequences of monocyte binding to minimally activated or thrombin-activated platelets.
Original languageEnglish
Pages (from-to)1491-8
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume28
Issue number8
DOIs
Publication statusPublished - Aug 2008

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