TY - JOUR
T1 - Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status
AU - Bournazos, Stylianos
AU - Rennie, Jillian
AU - Hart, Simon P
AU - Fox, Keith A A
AU - Dransfield, Ian
PY - 2008/8
Y1 - 2008/8
N2 - Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the mechanism of platelet binding to polymorphonuclear leukocytes, monocytes, and monocyte subsets and investigated the potential functional consequences of monocyte binding to minimally activated or thrombin-activated platelets.
AB - Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the mechanism of platelet binding to polymorphonuclear leukocytes, monocytes, and monocyte subsets and investigated the potential functional consequences of monocyte binding to minimally activated or thrombin-activated platelets.
UR - http://www.scopus.com/inward/record.url?scp=50249095930&partnerID=8YFLogxK
U2 - 10.1161/ATVBAHA.108.167601
DO - 10.1161/ATVBAHA.108.167601
M3 - Article
C2 - 18497306
SN - 1079-5642
VL - 28
SP - 1491
EP - 1498
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 8
ER -