Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status

Stylianos Bournazos; Jillian Rennie; Simon P Hart; Keith A A Fox; Ian Dransfield

doi:10.1161/ATVBAHA.108.167601

Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status

Stylianos Bournazos, Jillian Rennie, Simon P Hart, Keith A A Fox, Ian Dransfield

Research output: Contribution to journal › Article › peer-review

Abstract

Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the mechanism of platelet binding to polymorphonuclear leukocytes, monocytes, and monocyte subsets and investigated the potential functional consequences of monocyte binding to minimally activated or thrombin-activated platelets.

Original language	English
Pages (from-to)	1491-8
Number of pages	8
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	28
Issue number	8
DOIs	https://doi.org/10.1161/ATVBAHA.108.167601
Publication status	Published - Aug 2008

Access to Document

10.1161/ATVBAHA.108.167601

Cite this

@article{b1f3c91468a3458bb9d315ca06203769,

title = "Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status",

abstract = "Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the mechanism of platelet binding to polymorphonuclear leukocytes, monocytes, and monocyte subsets and investigated the potential functional consequences of monocyte binding to minimally activated or thrombin-activated platelets.",

author = "Stylianos Bournazos and Jillian Rennie and Hart, \{Simon P\} and Fox, \{Keith A A\} and Ian Dransfield",

year = "2008",

month = aug,

doi = "10.1161/ATVBAHA.108.167601",

language = "English",

volume = "28",

pages = "1491--8",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

publisher = "Lippincott Williams and Wilkins",

number = "8",

}

TY - JOUR

T1 - Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status

AU - Bournazos, Stylianos

AU - Rennie, Jillian

AU - Hart, Simon P

AU - Fox, Keith A A

AU - Dransfield, Ian

PY - 2008/8

Y1 - 2008/8

N2 - Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the mechanism of platelet binding to polymorphonuclear leukocytes, monocytes, and monocyte subsets and investigated the potential functional consequences of monocyte binding to minimally activated or thrombin-activated platelets.

AB - Acute coronary diseases are characterized by elevated levels of circulating platelet-leukocyte complexes, raising the possibility that proinflammatory processes might be initiated in leukocytes after platelet adhesion. Here we examined the mechanism of platelet binding to polymorphonuclear leukocytes, monocytes, and monocyte subsets and investigated the potential functional consequences of monocyte binding to minimally activated or thrombin-activated platelets.

UR - https://www.scopus.com/pages/publications/50249095930

U2 - 10.1161/ATVBAHA.108.167601

DO - 10.1161/ATVBAHA.108.167601

M3 - Article

C2 - 18497306

SN - 1079-5642

VL - 28

SP - 1491

EP - 1498

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 8

ER -

Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status

Abstract

Access to Document

Other files and links

Fingerprint

Cite this