Morphometry and Modeling of Label-Free Human Melanocytes and Melanoma Cells.

Sharareh Tavaddod, Behnaz Shojaedin-Givi, Mahnaz Mahmoudi-Rad, Hossein Naderi-Manesh

Research output: Contribution to journalArticlepeer-review


A combination of light microscopy and image processing was applied to investigate morphology of label-free primary-melanocytes and melanoma cells. A novel methodological approach based on morphology of nuclear body was used to find those single cells, which were at the same phase of cell cycle. The area and perimeter of melanocytes and melanoma cells were quantified. We found that there was a significant difference between area and perimeter of adendritic-shaped melanocytes with melanoma cells and the reason(s) of this finding was speculated. Finally, a theoretical model based on losing dendrites was proposed, which was in agreement with our experimental data.
Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalCell biochemistry and biophysics
Publication statusPublished - 14 Jan 2021


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