Motion-corrected imaging of the aortic valve with (18)F-NaF PET/CT and PET/MR: a feasibility study

Mhairi Doris, Mathieu Rubeaux, Tania Pawade, Yuka Otaki, Yibin Xie, Debiao Li, Balaji K Tamarappoo, David Newby, Daniel S Berman, Marc R Dweck, Piotr J Slomka, Damini Dey

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Abstract / Description of output

Introduction: We investigated whether motion correction of gated (18)F-fluoride PET-CT and PET-MR of the aortic valve could improve PET quantitation and image quality. Methods: A diffeomorphic, mass-preserving, anatomy-guided registration algorithm was used to align PET images from 4 cardiac gates, preserving all counts, and applied to PET-MR and PET-CT data of six patients with aortic stenosis. Measured Signal-to-Noise Ratios (SNRs) and Target-to-Background Ratios (TBRs) were compared with the standard method of utilizing only the diastolic gate. Results: High-intensity aortic valve (18)F-fluoride uptake was observed in all patients. Following motion correction, SNR and TBR increased compared to the diastolic gate (SNR 51.61 vs 21.0; TBR 2.85 vs 2.22) and summed data (SNR 51.61 vs 34.10, P = 0.028; TBR 2.85 vs 21.95, median, P = 0.028 for all). Furthermore, noise decreased from 0.105 (median, diastolic) to 0.042 (median, motion-corrected [P = 0.028]). Conclusion: Motion-correction of hybrid (18)F-fluoride PET markedly improves SNR, resulting in improved image quality.

Original languageEnglish
JournalJournal of Nuclear Medicine
Issue number11
Early online date25 May 2017
Publication statusPublished - 1 Nov 2017

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  • Journal Article


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