Mouse models of colorectal cancer as preclinical models

Rebecca E McIntyre, Simon J.A. Buczacki, Mark Arends, David J Adams

Research output: Contribution to journalArticlepeer-review

Abstract

In this review, we discuss the application of mouse models to the identification and pre-clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large-scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross-species comparative ‘omics-based approaches to this problem. We highlight recent progress in modelling late-stage disease using mice, and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection.
Original languageEnglish
JournalBioEssays
Volume37
Issue number8
Early online date26 Jun 2015
DOIs
Publication statusPublished - 1 Aug 2015

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