Abstract
The development of mouse models for cystic fibrosis has provided the opportunity to dissect disease pathogenesis, correlate genotype and phenotype, study disease-modifying genes and develop novel therapeutics. This review discusses the successes and the challenges encountered in characterizing and optimizing these models.
| Original language | English |
|---|---|
| Pages (from-to) | S29-37 |
| Journal | Trends in Genetics |
| Volume | 17 |
| Issue number | 10 |
| Publication status | Published - Oct 2001 |
Keywords
- Animals
- Cystic Fibrosis
- Disease Models, Animal
- Humans
- Intestinal Diseases
- Lung Diseases
- Mice
- Mice, Mutant Strains
- Pancreatic Diseases
- Phenotype