Mouse neuroimaging phenotyping in the cloud

Massimo Minervini*, Mario Damiano, Valter Tucci, Angelo Bifone, Alessandro Gozzi, Sotirios A. Tsaftaris

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

The combined use of mice that have genetic mutations (transgenic mouse models) of human pathology and advanced neuroimaging methods (such as MRI) has the potential to radically change how we approach disease understanding, diagnosis and treatment. Morphological changes occurring in the brain of transgenic animals as a result of the interaction between environment and genotype, can be assessed using advanced image analysis methods, an effort described as 'mouse brain phenotyping'. However, the computational methods required for the analysis of high-resolution brain images are demanding. In this paper, we propose a computationally effective cloud-based implementation of morphometric analysis of high-resolution mouse brain datasets. We show that the proposed approach is highly scalable and suited for a variety of methods for MR-based brain phenotyping. The proposed approach is easy to deploy, and could become an alternative for laboratories that may require instant access to large high performance computing infrastructure.

Original languageEnglish
Title of host publication2012 3rd International Conference on Image Processing Theory, Tools and Applications, IPTA 2012
Pages55-60
Number of pages6
DOIs
Publication statusPublished - 2012
Event2012 3rd International Conference on Image Processing Theory, Tools and Applications, IPTA 2012 - Istanbul, Turkey
Duration: 15 Oct 201218 Oct 2012

Conference

Conference2012 3rd International Conference on Image Processing Theory, Tools and Applications, IPTA 2012
Country/TerritoryTurkey
CityIstanbul
Period15/10/1218/10/12

Keywords / Materials (for Non-textual outputs)

  • cloud
  • computer vision
  • High performance computing
  • image analysis
  • MRI
  • neuroimaging
  • phenotyping

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