MRI of Creutzfeldt-Jakob disease: imaging features and recommended MRI protocol

D A Collie, R J Sellar, M Zeidler, A C Colchester, R Knight, R G Will, Robin Sellar

Research output: Contribution to journalArticlepeer-review

Abstract

Creutzfeldt-Jakob Disease (CJD) is a rare, progressive and invariably fatal neurodegenerative disease characterized by specific histopathological features. Of the four subtypes of CJD described, the commonest is sporadic CJD (sCJD). More recently, a new clinically distinct form of the disease affecting younger patients, known as variant CJD (vCJD), has been identified, and this has been causally linked to the bovine spongiform encephalopathy (BSE) agent in cattle. Characteristic appearances on magnetic resonance imaging (MRI) have been identified in several forms of CJD; sCJD may be associated with high signal changes in the putamen and caudate head and vCJD is usually associated with hyperintensity of the pulvinar (posterior nuclei) of the thalamus. These appearances and other imaging features are described in this article. Using appropriate clinical and radiological criteria and tailored imaging protocols, MRI plays an important part in the in vivodiagnosis of this disease.

Original languageEnglish
Pages (from-to)726-39
Number of pages14
JournalClinical Radiology
Volume56
Issue number9
DOIs
Publication statusPublished - Sep 2001

Keywords

  • Clinical Protocols
  • Creutzfeldt-Jakob Syndrome
  • Diagnosis, Differential
  • Humans
  • Magnetic Resonance Imaging
  • Pulvinar
  • Thalamus

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