mRNA-specific regulation of translation by poly(A)-binding proteins

Hannah M. Burgess, Nicola K. Gray

Research output: Contribution to journalArticlepeer-review

Abstract

The regulation of translation has emerged as a major determinant of gene expression and is critical for both normal cellular function and the development of disease Numerous studies have highlighted the diverse and sometimes related mechanisms which underlie the regulation of global translation rates and the translational control of specific mRNAs In the present paper we discuss the emerging roles of the basal translation factor PABP [poly(A) binding protein] in mRNA specific translational control in metazoa which suggest that PABP function is more complex than first recognized

Original languageEnglish
Pages (from-to)1517-1522
Number of pages6
JournalBiochemical Society Transactions
Volume38
Issue number6
DOIs
Publication statusPublished - Dec 2010

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