MS-SMART study: systematic sampling bias concerns - Authors' reply

MS -SMART Investigators

doi:10.1016/S1474-4422(20)30149-6

MS-SMART study: systematic sampling bias concerns - Authors' reply

MS -SMART Investigators

Research output: Contribution to journal › Letter › peer-review

Abstract / Description of output

We thank Lisa Grech and colleagues for their Correspondence concerning our Article on the MS-SMART trial. This multiarm phase 2b trial effectively condensed, into one well powered trial, the study of three re-purposed drugs with distinct mechanisms of action potentially relevant to slowing progression in secondary progressive multiple sclerosis. Despite positive experimental and early clinical work, unfortunately none of the drugs had any effect on slowing the rate of whole-brain atrophy (primary outcome), nor on a variety of secondary outcome measures.

Original language	English
Pages (from-to)	479-480
Number of pages	2
Journal	Lancet Neurology
Volume	19
Issue number	6
DOIs	https://doi.org/10.1016/S1474-4422(20)30149-6
Publication status	Published - 1 Jun 2020

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MS-SMART studyAccepted author manuscript, 421 KBLicence: CC BY-NC-ND

https://www.sciencedirect.com/science/article/pii/S1474442220301496?via%3Dihub

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title = "MS-SMART study: systematic sampling bias concerns - Authors' reply",

abstract = "We thank Lisa Grech and colleagues for their Correspondence concerning our Article on the MS-SMART trial. This multiarm phase 2b trial effectively condensed, into one well powered trial, the study of three re-purposed drugs with distinct mechanisms of action potentially relevant to slowing progression in secondary progressive multiple sclerosis. Despite positive experimental and early clinical work, unfortunately none of the drugs had any effect on slowing the rate of whole-brain atrophy (primary outcome), nor on a variety of secondary outcome measures.",

author = "{MS -SMART Investigators} and Jeremy Chataway and {De Angelis}, Floriana and Peter Connick and Parker, {Richard A} and Anisha Doshi and Nevin John and Frederik Barkhof and Basil Sharrack and Weir, {Christopher J} and Siddharthan Chandran",

year = "2020",

month = jun,

day = "1",

doi = "10.1016/S1474-4422(20)30149-6",

language = "English",

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TY - JOUR

T1 - MS-SMART study

T2 - systematic sampling bias concerns - Authors' reply

AU - MS -SMART Investigators

AU - Chataway, Jeremy

AU - De Angelis, Floriana

AU - Connick, Peter

AU - Parker, Richard A

AU - Doshi, Anisha

AU - John, Nevin

AU - Barkhof, Frederik

AU - Sharrack, Basil

AU - Weir, Christopher J

AU - Chandran, Siddharthan

PY - 2020/6/1

Y1 - 2020/6/1

N2 - We thank Lisa Grech and colleagues for their Correspondence concerning our Article on the MS-SMART trial. This multiarm phase 2b trial effectively condensed, into one well powered trial, the study of three re-purposed drugs with distinct mechanisms of action potentially relevant to slowing progression in secondary progressive multiple sclerosis. Despite positive experimental and early clinical work, unfortunately none of the drugs had any effect on slowing the rate of whole-brain atrophy (primary outcome), nor on a variety of secondary outcome measures.

AB - We thank Lisa Grech and colleagues for their Correspondence concerning our Article on the MS-SMART trial. This multiarm phase 2b trial effectively condensed, into one well powered trial, the study of three re-purposed drugs with distinct mechanisms of action potentially relevant to slowing progression in secondary progressive multiple sclerosis. Despite positive experimental and early clinical work, unfortunately none of the drugs had any effect on slowing the rate of whole-brain atrophy (primary outcome), nor on a variety of secondary outcome measures.

U2 - 10.1016/S1474-4422(20)30149-6

DO - 10.1016/S1474-4422(20)30149-6

M3 - Letter

C2 - 32470412

SN - 1474-4422

VL - 19

SP - 479

EP - 480

JO - Lancet Neurology

JF - Lancet Neurology

IS - 6

ER -

MS-SMART study: systematic sampling bias concerns - Authors' reply

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