Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19

COVID-19 Host Genetics Initiative

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) derived from Neanderthals in the chromosomal region 12q24.13. This haplotype contains a splice variant of OAS1, which occurs in people of African ancestry independently of gene flow from Neanderthals. Using trans-ancestry fine-mapping approaches in 20,779 hospitalized cases, we demonstrate that this splice variant is likely to be the SNP responsible for the association at this locus, thus strongly implicating OAS1 as an effector gene influencing COVID-19 severity.

Original languageEnglish
Pages (from-to)125-127
JournalNature Genetics
Issue number2
Early online date13 Jan 2022
Publication statusPublished - Feb 2022

Keywords / Materials (for Non-textual outputs)

  • 2',5'-Oligoadenylate Synthetase/genetics
  • Blacks/genetics
  • COVID-19/enzymology
  • Genetic Predisposition to Disease
  • Humans
  • Linkage Disequilibrium/genetics
  • Physical Chromosome Mapping
  • RNA Splicing/genetics
  • Risk Factors
  • Severity of Illness Index
  • Whites/genetics


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