Projects per year
Abstract
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Original language | English |
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Pages (from-to) | 636-648 |
Number of pages | 13 |
Journal | Nature Genetics |
Volume | 51 |
Issue number | 4 |
DOIs | |
Publication status | Published - 29 Mar 2019 |
Keywords / Materials (for Non-textual outputs)
- cardiovascular diseases
- genome-wide association studies
- genomics
Fingerprint
Dive into the research topics of 'Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids'. Together they form a unique fingerprint.Projects
- 3 Finished
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RA2665 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
1/09/13 → 31/08/19
Project: Research
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A genome wide association study of non pathological cognitive ageing
Deary, I., Porteous, D. & Tenesa, A.
1/09/08 → 31/08/10
Project: Research
Profiles
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Caroline Hayward
- Deanery of Molecular, Genetic and Population Health Sciences - UoE Retired Staff
- MRC Human Genetics Unit
Person: Academic: Research Active , Affiliated Independent Researcher