Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

Benjamin F J Verhaaren; Stéphanie Debette; Joshua C Bis; Jennifer A Smith; M Kamran Ikram; Hieab H Adams; Ashley H Beecham; Kumar B Rajan; Lorna M Lopez; Sandra Barral; Mark A van Buchem; Jeroen van der Grond; Albert V Smith; Katrin Hegenscheid; Neelum T Aggarwal; Mariza de Andrade; Elizabeth J Atkinson; Marian Beekman; Alexa S Beiser; Susan H Blanton; Eric Boerwinkle; Adam M Brickman; R Nick Bryan; Ganesh Chauhan; Christopher P L H Chen; Vincent Chouraki; Anton J M de Craen; Fabrice Crivello; Ian J Deary; Joris Deelen; Philip L De Jager; Carole Dufouil; Mitchell S V Elkind; Denis A Evans; Paul Freudenberger; Rebecca F Gottesman; Vilmundur Guðnason; Mohamad Habes; Susan R Heckbert; Gerardo Heiss; Saima Hilal; Edith Hofer; Albert Hofman; Carla A Ibrahim-Verbaas; David S Knopman; Cora E Lewis; Jiemin Liao; David C M Liewald; Michelle Luciano; Aad van der Lugt; Oliver O Martinez; Richard Mayeux; Bernard Mazoyer; Michael A Nalls; Matthias Nauck; Wiro J Niessen; Ben A Oostra; Bruce M Psaty; Kenneth M Rice; Jerome I Rotter; Bettina von Sarnowski; Helena Schmidt; Pamela J Schreiner; Maaike Schuur; Stephen S Sidney; Sigurdur Sigurdsson; P Eline Slagboom; David J M Stott; John C van Swieten; Alexander Teumer; Anna Maria Töglhofer; Matthew Traylor; Stella Trompet; Stephen T Turner; Christophe Tzourio; Hae-Won Uh; André G Uitterlinden; Meike W Vernooij; Jing J Wang; Tien Y Wong; Joanna M Wardlaw; B Gwen Windham; Katharina Wittfeld; Christiane Wolf; Clinton B Wright; Qiong Yang; Wei Zhao; Alex Zijdenbos; J Wouter Jukema; Ralph L Sacco; Sharon L R Kardia; Philippe Amouyel; Thomas H Mosley; W T Longstreth; Charles C DeCarli; Cornelia M van Duijn; Reinhold Schmidt; Lenore J Launer; Hans J Grabe; Sudha S Seshadri; M Arfan Ikram; Myriam Fornage

doi:10.1161/CIRCGENETICS.114.000858

Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

Benjamin F J Verhaaren, Stéphanie Debette, Joshua C Bis, Jennifer A Smith, M Kamran Ikram, Hieab H Adams, Ashley H Beecham, Kumar B Rajan, Lorna M Lopez, Sandra Barral, Mark A van Buchem, Jeroen van der Grond, Albert V Smith, Katrin Hegenscheid, Neelum T Aggarwal, Mariza de Andrade, Elizabeth J Atkinson, Marian Beekman, Alexa S Beiser, Susan H BlantonEric Boerwinkle, Adam M Brickman, R Nick Bryan, Ganesh Chauhan, Christopher P L H Chen, Vincent Chouraki, Anton J M de Craen, Fabrice Crivello, Ian J Deary, Joris Deelen, Philip L De Jager, Carole Dufouil, Mitchell S V Elkind, Denis A Evans, Paul Freudenberger, Rebecca F Gottesman, Vilmundur Guðnason, Mohamad Habes, Susan R Heckbert, Gerardo Heiss, Saima Hilal, Edith Hofer, Albert Hofman, Carla A Ibrahim-Verbaas, David S Knopman, Cora E Lewis, Jiemin Liao, David C M Liewald, Michelle Luciano, Aad van der Lugt, Oliver O Martinez, Richard Mayeux, Bernard Mazoyer, Michael A Nalls, Matthias Nauck, Wiro J Niessen, Ben A Oostra, Bruce M Psaty, Kenneth M Rice, Jerome I Rotter, Bettina von Sarnowski, Helena Schmidt, Pamela J Schreiner, Maaike Schuur, Stephen S Sidney, Sigurdur Sigurdsson, P Eline Slagboom, David J M Stott, John C van Swieten, Alexander Teumer, Anna Maria Töglhofer, Matthew Traylor, Stella Trompet, Stephen T Turner, Christophe Tzourio, Hae-Won Uh, André G Uitterlinden, Meike W Vernooij, Jing J Wang, Tien Y Wong, Joanna M Wardlaw, B Gwen Windham, Katharina Wittfeld, Christiane Wolf, Clinton B Wright, Qiong Yang, Wei Zhao, Alex Zijdenbos, J Wouter Jukema, Ralph L Sacco, Sharon L R Kardia, Philippe Amouyel, Thomas H Mosley, W T Longstreth, Charles C DeCarli, Cornelia M van Duijn, Reinhold Schmidt, Lenore J Launer, Hans J Grabe, Sudha S Seshadri, M Arfan Ikram, Myriam Fornage^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: -The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multi-ethnic genome-wide association studies.

METHODS AND RESULTS: -We included 21,079 middle-aged to elderly individuals from 29 population-based cohorts, who were free of dementia and stroke and were of European (N=17,936), African (N=1,943), Hispanic (N=795), and Asian (N=405) descent. WMH burden was quantified on MRI either by a validated automated segmentation method or a validated visual grading scale. Genotype data in each study were imputed to the 1000 Genomes reference. Within each ethnic group, we investigated the relationship between each SNP and WMH burden using a linear regression model adjusted for age, sex, intracranial volume, and principal components of ancestry. A meta-analysis was conducted for each ethnicity separately and for the combined sample. In the European descent samples, we confirmed a previously known locus on chr17q25 (p=2.7×10(-19)) and identified novel loci on chr10q24 (p=1.6×10(-9)) and chr2p21 (p=4.4×10(-8)). In the multi-ethnic meta-analysis, we identified two additional loci, on chr1q22 (p=2.0×10(-8)) and chr2p16 (p=1.5×10(-8)). The novel loci contained genes that have been implicated in Alzheimer's disease (chr2p21, chr10q24), intracerebral hemorrhage (chr1q22), neuro-inflammatory diseases (chr2p21), and glioma (chr10q24, chr2p16).

CONCLUSIONS: -We identified four novel genetic loci that implicate inflammatory and glial proliferative pathways in the development of white matter hyperintensities in addition to previously-proposed ischemic mechanisms.

Original language	English
Pages (from-to)	398-+
Number of pages	54
Journal	Circulation: Cardiovascular Genetics
Volume	8
Issue number	2
Early online date	7 Feb 2015
DOIs	https://doi.org/10.1161/CIRCGENETICS.114.000858
Publication status	Published - Apr 2015

Keywords / Materials (for Non-textual outputs)

cerebral small vessel diseases
cerebrovascular disorders
genome-wide association study
hypertension
leukoencephalopathies
polymorphisms, single nucleotide
AUSTRIAN STROKE PREVENTION
SMALL-VESSEL DISEASE
CENTRAL CORNEAL THICKNESS
ONSET ALZHEIMERS-DISEASE
CARDIOVASCULAR HEALTH
ISCHEMIC-STROKE
COGNITIVE IMPAIRMENT
NORTHERN MANHATTAN
KYNURENINE PATHWAY
VASCULAR-DISEASE

Access to Document

10.1161/CIRCGENETICS.114.000858

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A.
1/09/13 → 31/08/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I., Gale, C., Holmes, M., Logie, P., Maclullich, A., Porteous, D., Seckl, J., Starr, J., Wardlaw, J. & Okely, J.
1/09/13 → 31/08/19
Project: Research
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I., Bastin, M., Penke, L., Starr, J. & Wardlaw, J.
MRC
8/06/11 → 7/03/15
Project: Research

Cite this

Verhaaren, B. F. J., Debette, S., Bis, J. C., Smith, J. A., Ikram, M. K., Adams, H. H., Beecham, A. H., Rajan, K. B., Lopez, L. M., Barral, S., van Buchem, M. A., van der Grond, J., Smith, A. V., Hegenscheid, K., Aggarwal, N. T., de Andrade, M., Atkinson, E. J., Beekman, M., Beiser, A. S., ... Fornage, M. (2015). Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI. Circulation: Cardiovascular Genetics, 8(2), 398-+. https://doi.org/10.1161/CIRCGENETICS.114.000858

@article{deff53e27b804d8f93b8accba5b5582c,

title = "Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI",

abstract = "BACKGROUND: -The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multi-ethnic genome-wide association studies.METHODS AND RESULTS: -We included 21,079 middle-aged to elderly individuals from 29 population-based cohorts, who were free of dementia and stroke and were of European (N=17,936), African (N=1,943), Hispanic (N=795), and Asian (N=405) descent. WMH burden was quantified on MRI either by a validated automated segmentation method or a validated visual grading scale. Genotype data in each study were imputed to the 1000 Genomes reference. Within each ethnic group, we investigated the relationship between each SNP and WMH burden using a linear regression model adjusted for age, sex, intracranial volume, and principal components of ancestry. A meta-analysis was conducted for each ethnicity separately and for the combined sample. In the European descent samples, we confirmed a previously known locus on chr17q25 (p=2.7×10(-19)) and identified novel loci on chr10q24 (p=1.6×10(-9)) and chr2p21 (p=4.4×10(-8)). In the multi-ethnic meta-analysis, we identified two additional loci, on chr1q22 (p=2.0×10(-8)) and chr2p16 (p=1.5×10(-8)). The novel loci contained genes that have been implicated in Alzheimer's disease (chr2p21, chr10q24), intracerebral hemorrhage (chr1q22), neuro-inflammatory diseases (chr2p21), and glioma (chr10q24, chr2p16).CONCLUSIONS: -We identified four novel genetic loci that implicate inflammatory and glial proliferative pathways in the development of white matter hyperintensities in addition to previously-proposed ischemic mechanisms.",

keywords = "cerebral small vessel diseases, cerebrovascular disorders, genome-wide association study, hypertension, leukoencephalopathies, polymorphisms, single nucleotide, AUSTRIAN STROKE PREVENTION, SMALL-VESSEL DISEASE, CENTRAL CORNEAL THICKNESS, ONSET ALZHEIMERS-DISEASE, CARDIOVASCULAR HEALTH, ISCHEMIC-STROKE, COGNITIVE IMPAIRMENT, NORTHERN MANHATTAN, KYNURENINE PATHWAY, VASCULAR-DISEASE",

author = "Verhaaren, {Benjamin F J} and St{\'e}phanie Debette and Bis, {Joshua C} and Smith, {Jennifer A} and Ikram, {M Kamran} and Adams, {Hieab H} and Beecham, {Ashley H} and Rajan, {Kumar B} and Lopez, {Lorna M} and Sandra Barral and {van Buchem}, {Mark A} and {van der Grond}, Jeroen and Smith, {Albert V} and Katrin Hegenscheid and Aggarwal, {Neelum T} and {de Andrade}, Mariza and Atkinson, {Elizabeth J} and Marian Beekman and Beiser, {Alexa S} and Blanton, {Susan H} and Eric Boerwinkle and Brickman, {Adam M} and Bryan, {R Nick} and Ganesh Chauhan and Chen, {Christopher P L H} and Vincent Chouraki and {de Craen}, {Anton J M} and Fabrice Crivello and Deary, {Ian J} and Joris Deelen and {De Jager}, {Philip L} and Carole Dufouil and Elkind, {Mitchell S V} and Evans, {Denis A} and Paul Freudenberger and Gottesman, {Rebecca F} and Vilmundur Gu{\dh}nason and Mohamad Habes and Heckbert, {Susan R} and Gerardo Heiss and Saima Hilal and Edith Hofer and Albert Hofman and Ibrahim-Verbaas, {Carla A} and Knopman, {David S} and Lewis, {Cora E} and Jiemin Liao and Liewald, {David C M} and Michelle Luciano and {van der Lugt}, Aad and Martinez, {Oliver O} and Richard Mayeux and Bernard Mazoyer and Nalls, {Michael A} and Matthias Nauck and Niessen, {Wiro J} and Oostra, {Ben A} and Psaty, {Bruce M} and Rice, {Kenneth M} and Rotter, {Jerome I} and {von Sarnowski}, Bettina and Helena Schmidt and Schreiner, {Pamela J} and Maaike Schuur and Sidney, {Stephen S} and Sigurdur Sigurdsson and Slagboom, {P Eline} and Stott, {David J M} and {van Swieten}, {John C} and Alexander Teumer and T{\"o}glhofer, {Anna Maria} and Matthew Traylor and Stella Trompet and Turner, {Stephen T} and Christophe Tzourio and Hae-Won Uh and Uitterlinden, {Andr{\'e} G} and Vernooij, {Meike W} and Wang, {Jing J} and Wong, {Tien Y} and Wardlaw, {Joanna M} and Windham, {B Gwen} and Katharina Wittfeld and Christiane Wolf and Wright, {Clinton B} and Qiong Yang and Wei Zhao and Alex Zijdenbos and Jukema, {J Wouter} and Sacco, {Ralph L} and Kardia, {Sharon L R} and Philippe Amouyel and Mosley, {Thomas H} and Longstreth, {W T} and DeCarli, {Charles C} and {van Duijn}, {Cornelia M} and Reinhold Schmidt and Launer, {Lenore J} and Grabe, {Hans J} and Seshadri, {Sudha S} and Ikram, {M Arfan} and Myriam Fornage",

year = "2015",

month = apr,

doi = "10.1161/CIRCGENETICS.114.000858",

language = "English",

volume = "8",

pages = "398--+",

journal = "Circulation: Cardiovascular Genetics",

issn = "1942-325X",

publisher = "Lippincott Williams & Wilkins",

number = "2",

}

Verhaaren, BFJ, Debette, S, Bis, JC, Smith, JA, Ikram, MK, Adams, HH, Beecham, AH, Rajan, KB, Lopez, LM, Barral, S, van Buchem, MA, van der Grond, J, Smith, AV, Hegenscheid, K, Aggarwal, NT, de Andrade, M, Atkinson, EJ, Beekman, M, Beiser, AS, Blanton, SH, Boerwinkle, E, Brickman, AM, Bryan, RN, Chauhan, G, Chen, CPLH, Chouraki, V, de Craen, AJM, Crivello, F, Deary, IJ, Deelen, J, De Jager, PL, Dufouil, C, Elkind, MSV, Evans, DA, Freudenberger, P, Gottesman, RF, Guðnason, V, Habes, M, Heckbert, SR, Heiss, G, Hilal, S, Hofer, E, Hofman, A, Ibrahim-Verbaas, CA, Knopman, DS, Lewis, CE, Liao, J, Liewald, DCM, Luciano, M, van der Lugt, A, Martinez, OO, Mayeux, R, Mazoyer, B, Nalls, MA, Nauck, M, Niessen, WJ, Oostra, BA, Psaty, BM, Rice, KM, Rotter, JI, von Sarnowski, B, Schmidt, H, Schreiner, PJ, Schuur, M, Sidney, SS, Sigurdsson, S, Slagboom, PE, Stott, DJM, van Swieten, JC, Teumer, A, Töglhofer, AM, Traylor, M, Trompet, S, Turner, ST, Tzourio, C, Uh, H-W, Uitterlinden, AG, Vernooij, MW, Wang, JJ, Wong, TY, Wardlaw, JM, Windham, BG, Wittfeld, K, Wolf, C, Wright, CB, Yang, Q, Zhao, W, Zijdenbos, A, Jukema, JW, Sacco, RL, Kardia, SLR, Amouyel, P, Mosley, TH, Longstreth, WT, DeCarli, CC, van Duijn, CM, Schmidt, R, Launer, LJ, Grabe, HJ, Seshadri, SS, Ikram, MA & Fornage, M 2015, 'Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI', Circulation: Cardiovascular Genetics, vol. 8, no. 2, pp. 398-+. https://doi.org/10.1161/CIRCGENETICS.114.000858

TY - JOUR

T1 - Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

AU - Verhaaren, Benjamin F J

AU - Debette, Stéphanie

AU - Bis, Joshua C

AU - Smith, Jennifer A

AU - Ikram, M Kamran

AU - Adams, Hieab H

AU - Beecham, Ashley H

AU - Rajan, Kumar B

AU - Lopez, Lorna M

AU - Barral, Sandra

AU - van Buchem, Mark A

AU - van der Grond, Jeroen

AU - Smith, Albert V

AU - Hegenscheid, Katrin

AU - Aggarwal, Neelum T

AU - de Andrade, Mariza

AU - Atkinson, Elizabeth J

AU - Beekman, Marian

AU - Beiser, Alexa S

AU - Blanton, Susan H

AU - Boerwinkle, Eric

AU - Brickman, Adam M

AU - Bryan, R Nick

AU - Chauhan, Ganesh

AU - Chen, Christopher P L H

AU - Chouraki, Vincent

AU - de Craen, Anton J M

AU - Crivello, Fabrice

AU - Deary, Ian J

AU - Deelen, Joris

AU - De Jager, Philip L

AU - Dufouil, Carole

AU - Elkind, Mitchell S V

AU - Evans, Denis A

AU - Freudenberger, Paul

AU - Gottesman, Rebecca F

AU - Guðnason, Vilmundur

AU - Habes, Mohamad

AU - Heckbert, Susan R

AU - Heiss, Gerardo

AU - Hilal, Saima

AU - Hofer, Edith

AU - Hofman, Albert

AU - Ibrahim-Verbaas, Carla A

AU - Knopman, David S

AU - Lewis, Cora E

AU - Liao, Jiemin

AU - Liewald, David C M

AU - Luciano, Michelle

AU - van der Lugt, Aad

AU - Martinez, Oliver O

AU - Mayeux, Richard

AU - Mazoyer, Bernard

AU - Nalls, Michael A

AU - Nauck, Matthias

AU - Niessen, Wiro J

AU - Oostra, Ben A

AU - Psaty, Bruce M

AU - Rice, Kenneth M

AU - Rotter, Jerome I

AU - von Sarnowski, Bettina

AU - Schmidt, Helena

AU - Schreiner, Pamela J

AU - Schuur, Maaike

AU - Sidney, Stephen S

AU - Sigurdsson, Sigurdur

AU - Slagboom, P Eline

AU - Stott, David J M

AU - van Swieten, John C

AU - Teumer, Alexander

AU - Töglhofer, Anna Maria

AU - Traylor, Matthew

AU - Trompet, Stella

AU - Turner, Stephen T

AU - Tzourio, Christophe

AU - Uh, Hae-Won

AU - Uitterlinden, André G

AU - Vernooij, Meike W

AU - Wang, Jing J

AU - Wong, Tien Y

AU - Wardlaw, Joanna M

AU - Windham, B Gwen

AU - Wittfeld, Katharina

AU - Wolf, Christiane

AU - Wright, Clinton B

AU - Yang, Qiong

AU - Zhao, Wei

AU - Zijdenbos, Alex

AU - Jukema, J Wouter

AU - Sacco, Ralph L

AU - Kardia, Sharon L R

AU - Amouyel, Philippe

AU - Mosley, Thomas H

AU - Longstreth, W T

AU - DeCarli, Charles C

AU - van Duijn, Cornelia M

AU - Schmidt, Reinhold

AU - Launer, Lenore J

AU - Grabe, Hans J

AU - Seshadri, Sudha S

AU - Ikram, M Arfan

AU - Fornage, Myriam

PY - 2015/4

Y1 - 2015/4

N2 - BACKGROUND: -The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multi-ethnic genome-wide association studies.METHODS AND RESULTS: -We included 21,079 middle-aged to elderly individuals from 29 population-based cohorts, who were free of dementia and stroke and were of European (N=17,936), African (N=1,943), Hispanic (N=795), and Asian (N=405) descent. WMH burden was quantified on MRI either by a validated automated segmentation method or a validated visual grading scale. Genotype data in each study were imputed to the 1000 Genomes reference. Within each ethnic group, we investigated the relationship between each SNP and WMH burden using a linear regression model adjusted for age, sex, intracranial volume, and principal components of ancestry. A meta-analysis was conducted for each ethnicity separately and for the combined sample. In the European descent samples, we confirmed a previously known locus on chr17q25 (p=2.7×10(-19)) and identified novel loci on chr10q24 (p=1.6×10(-9)) and chr2p21 (p=4.4×10(-8)). In the multi-ethnic meta-analysis, we identified two additional loci, on chr1q22 (p=2.0×10(-8)) and chr2p16 (p=1.5×10(-8)). The novel loci contained genes that have been implicated in Alzheimer's disease (chr2p21, chr10q24), intracerebral hemorrhage (chr1q22), neuro-inflammatory diseases (chr2p21), and glioma (chr10q24, chr2p16).CONCLUSIONS: -We identified four novel genetic loci that implicate inflammatory and glial proliferative pathways in the development of white matter hyperintensities in addition to previously-proposed ischemic mechanisms.

AB - BACKGROUND: -The burden of cerebral white matter hyperintensities (WMH) is associated with an increased risk of stroke, dementia, and death. WMH are highly heritable, but their genetic underpinnings are incompletely characterized. To identify novel genetic variants influencing WMH burden, we conducted a meta-analysis of multi-ethnic genome-wide association studies.METHODS AND RESULTS: -We included 21,079 middle-aged to elderly individuals from 29 population-based cohorts, who were free of dementia and stroke and were of European (N=17,936), African (N=1,943), Hispanic (N=795), and Asian (N=405) descent. WMH burden was quantified on MRI either by a validated automated segmentation method or a validated visual grading scale. Genotype data in each study were imputed to the 1000 Genomes reference. Within each ethnic group, we investigated the relationship between each SNP and WMH burden using a linear regression model adjusted for age, sex, intracranial volume, and principal components of ancestry. A meta-analysis was conducted for each ethnicity separately and for the combined sample. In the European descent samples, we confirmed a previously known locus on chr17q25 (p=2.7×10(-19)) and identified novel loci on chr10q24 (p=1.6×10(-9)) and chr2p21 (p=4.4×10(-8)). In the multi-ethnic meta-analysis, we identified two additional loci, on chr1q22 (p=2.0×10(-8)) and chr2p16 (p=1.5×10(-8)). The novel loci contained genes that have been implicated in Alzheimer's disease (chr2p21, chr10q24), intracerebral hemorrhage (chr1q22), neuro-inflammatory diseases (chr2p21), and glioma (chr10q24, chr2p16).CONCLUSIONS: -We identified four novel genetic loci that implicate inflammatory and glial proliferative pathways in the development of white matter hyperintensities in addition to previously-proposed ischemic mechanisms.

KW - cerebral small vessel diseases

KW - cerebrovascular disorders

KW - genome-wide association study

KW - hypertension

KW - leukoencephalopathies

KW - polymorphisms, single nucleotide

KW - AUSTRIAN STROKE PREVENTION

KW - SMALL-VESSEL DISEASE

KW - CENTRAL CORNEAL THICKNESS

KW - ONSET ALZHEIMERS-DISEASE

KW - CARDIOVASCULAR HEALTH

KW - ISCHEMIC-STROKE

KW - COGNITIVE IMPAIRMENT

KW - NORTHERN MANHATTAN

KW - KYNURENINE PATHWAY

KW - VASCULAR-DISEASE

U2 - 10.1161/CIRCGENETICS.114.000858

DO - 10.1161/CIRCGENETICS.114.000858

M3 - Article

C2 - 25663218

SN - 1942-325X

VL - 8

SP - 398-+

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

IS - 2

ER -

Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI

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Keywords / Materials (for Non-textual outputs)

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Projects

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II

Cite this