Multi-frequency Electromagnetic Tomography for Acute Stroke Detection Using Frequency-Constrained Sparse Bayesian Learning

Jinxi Xiang, Yonggui Dong, Yunjie Yang

Research output: Contribution to journalArticlepeer-review

Abstract

Imaging the bio-impedance distribution of the brain can provide initial diagnosis of acute stroke. This paper presents a compact and non-radiative tomographic modality, i.e. multi-frequency Electromagnetic Tomography (mfEMT), for the initial diagnosis of acute stroke. The mfEMT system consists of 12 channels of gradiometer coils with adjustable sensitivity and excitation frequency. To solve the image reconstruction problem of mfEMT, we propose an enhanced Frequency-Constrained Sparse Bayesian Learning (FC-SBL) to simultaneously reconstruct the conductivity distribution at all frequencies. Based on the Multiple Measurement Vector (MMV) model in the Sparse Bayesian Learning (SBL) framework, FC-SBL can recover the underlying distribution pattern of conductivity among multiple images by exploiting the frequency constraint information. A realistic 3D head model was established to simulate stroke detection scenarios, showing the capability of mfEMT to penetrate the highly resistive skull and improved image quality with FC-SBL. Both simulations and experiments showed that the proposed FC-SBL method is robust to noisy data for image reconstruction problems of mfEMT compared to the single measurement vector model, which is promising to detect acute strokes in the brain region with enhanced spatial resolution and in a baseline-free manner.
Original languageEnglish
Pages (from-to)4102 - 4112
Number of pages11
JournalIEEE Transactions on Medical Imaging
Volume39
Issue number12
Early online date30 Jul 2020
DOIs
Publication statusPublished - 31 Dec 2020

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