Multi-objective Dynamic Optimisation of Ampicillin Batch Crystallisation

Antonios Dafnomilis; Samir Diab; Alistair D. Rodman; Andreas G. Boudouvis; Dimitrios I. Gerogiorgis

doi:10.1016/B978-0-12-823377-1.50073-2

Multi-objective Dynamic Optimisation of Ampicillin Batch Crystallisation

Antonios Dafnomilis, Samir Diab, Alistair D. Rodman, Andreas G. Boudouvis, Dimitrios I. Gerogiorgis

School of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Ampicillin is a key β-lactam antibiotic listed as a World Health Organisation (WHO) Essential Medicine. Crystallisation is a unit operation of paramount importance in pharmaceutical manufacturing, whose design and operation are essential in controlling process yield and important product quality attributes, such as mean product crystal size (MCS) and size distribution width. A published model for the solubility of ampicillin as a function of pH as well as growth and nucleation kinetics is used towards the simulation and optimisation of its batch crystallisation. This study performs multi-objective dynamic optimisation of the batch crystallisation of ampicillin to establish optimal pH trajectories for different production objectives, including maximising the mean crystal size whilst minimising the size distribution width subject to various yield constraints. Trade-offs between different product quality attributes are thus quantified, visualised and discussed.

Original language	English
Title of host publication	Computer Aided Chemical Engineering
Subtitle of host publication	30th European Symposium on Computer Aided Process Engineering
Editors	Sauro Pierucci, Flavio Manenti, Giulia Luisa Bozzano, Davide Manca
Publisher	Elsevier
Pages	433-438
Number of pages	6
Volume	48
ISBN (Print)	1570-7946
DOIs	https://doi.org/10.1016/B978-0-12-823377-1.50073-2
Publication status	Published - 19 Oct 2020
Event	30th European Symposium on Computer Aided Process Engineering - Online, Milan, Italy Duration: 31 Aug 2020 → 2 Sep 2020 https://www.aidic.it/escape30/enter.php

Publication series

Name	Computer Aided Chemical Engineering
Publisher	Elsevier
Volume	48
ISSN (Print)	1570-7946

Conference

Conference	30th European Symposium on Computer Aided Process Engineering
Abbreviated title	ESCAPE 30
Country/Territory	Italy
City	Milan
Period	31/08/20 → 2/09/20
Internet address	https://www.aidic.it/escape30/enter.php

Keywords

Multi-objective dynamic optimisation
batch crystallisation
ampicillin

Access to Document

10.1016/B978-0-12-823377-1.50073-2

362DafnomilisAccepted author manuscript, 1.19 MB

http://www.sciencedirect.com/science/article/pii/B9780128233771500732

Cite this

Dafnomilis, A., Diab, S., Rodman, A. D., Boudouvis, A. G., & Gerogiorgis, D. I. (2020). Multi-objective Dynamic Optimisation of Ampicillin Batch Crystallisation. In S. Pierucci, F. Manenti, G. L. Bozzano, & D. Manca (Eds.), Computer Aided Chemical Engineering: 30th European Symposium on Computer Aided Process Engineering (Vol. 48, pp. 433-438). (Computer Aided Chemical Engineering; Vol. 48). Elsevier. https://doi.org/10.1016/B978-0-12-823377-1.50073-2

Dafnomilis, Antonios ; Diab, Samir ; Rodman, Alistair D. ; Boudouvis, Andreas G. ; Gerogiorgis, Dimitrios I. / Multi-objective Dynamic Optimisation of Ampicillin Batch Crystallisation. Computer Aided Chemical Engineering: 30th European Symposium on Computer Aided Process Engineering. editor / Sauro Pierucci ; Flavio Manenti ; Giulia Luisa Bozzano ; Davide Manca. Vol. 48 Elsevier, 2020. pp. 433-438 (Computer Aided Chemical Engineering).

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Dafnomilis, A, Diab, S, Rodman, AD, Boudouvis, AG & Gerogiorgis, DI 2020, Multi-objective Dynamic Optimisation of Ampicillin Batch Crystallisation. in S Pierucci, F Manenti, GL Bozzano & D Manca (eds), Computer Aided Chemical Engineering: 30th European Symposium on Computer Aided Process Engineering. vol. 48, Computer Aided Chemical Engineering, vol. 48, Elsevier, pp. 433-438, 30th European Symposium on Computer Aided Process Engineering, Milan, Italy, 31/08/20. https://doi.org/10.1016/B978-0-12-823377-1.50073-2

Multi-objective Dynamic Optimisation of Ampicillin Batch Crystallisation. / Dafnomilis, Antonios; Diab, Samir; Rodman, Alistair D.; Boudouvis, Andreas G.; Gerogiorgis, Dimitrios I.

Computer Aided Chemical Engineering: 30th European Symposium on Computer Aided Process Engineering. ed. / Sauro Pierucci; Flavio Manenti; Giulia Luisa Bozzano; Davide Manca. Vol. 48 Elsevier, 2020. p. 433-438 (Computer Aided Chemical Engineering; Vol. 48).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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AU - Dafnomilis, Antonios

AU - Diab, Samir

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AU - Boudouvis, Andreas G.

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ER -

Dafnomilis A, Diab S, Rodman AD, Boudouvis AG, Gerogiorgis DI. Multi-objective Dynamic Optimisation of Ampicillin Batch Crystallisation. In Pierucci S, Manenti F, Bozzano GL, Manca D, editors, Computer Aided Chemical Engineering: 30th European Symposium on Computer Aided Process Engineering. Vol. 48. Elsevier. 2020. p. 433-438. (Computer Aided Chemical Engineering). https://doi.org/10.1016/B978-0-12-823377-1.50073-2

Multi-objective Dynamic Optimisation of Ampicillin Batch Crystallisation

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Keywords

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