Multicenter European Prevalence Study of Neurocognitive Impairment and Associated Factors in HIV Positive Patients

L.J. Haddow, R. Laverick, M. Daskalopoulou, J. McDonnell, F.C. Lampe, R. Gilson, A. Speakman, A. Antinori, P. Balestra, T. Bruun, J. Gerstoft, L. Nielsen, A. Vassilenko, S. Collins, Alison J. Rodger, T.C.I.I.P.W.H.I.T.E.R.C.S.G. For

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Abstract

© 2017 The Author(s)We conducted a cross-sectional study in 448 HIV positive patients attending five European outpatient clinics to determine prevalence of and factors associated with neurocognitive impairment (NCI) using computerized and pen-and-paper neuropsychological tests. NCI was defined as a normalized Z score ≤−1 in at least 2 out of 5 cognitive domains. Participants’ mean age was 45.8 years; 84% male; 87% white; 56% university educated; median CD4 count 550 cells/mm3; 89% on antiretroviral therapy. 156 (35%) participants had NCI, among whom 26 (17%; 5.8% overall) reported a decline in activities of daily living. Prevalence of NCI was lower in those always able to afford basic needs (adjusted prevalence ratio [aPR] 0.71, 95% confidence interval [CI] 0.54–0.94) or with a university education (aPR 0.72, 95% CI 0.54–0.97) and higher in those with severe depressive symptoms (aPR 1.53, 95% CI 1.09–2.14) or a significant comorbid condition (aPR 1.40, 95% CI 1.03–1.90).
Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalAIDS and Behavior
DOIs
Publication statusPublished - 31 Jan 2017

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