Abstract / Description of output
Apathy is prevalent in dementia, such as behavioural variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA) and Alzheimer’s disease (AD). As a multidimensional construct, it can be assessed and subsumed under a Dimensional Apathy Framework. A consistent apathy profile in bvFTD and PPA has yet to be established. The aim was to explore apathy profiles and awareness in bvFTD, PPA and AD. 12 bvFTD, 12 PPA, 28 AD patients and 20 matched controls, as well as their informants/carers, were recruited. All participants completed the Dimensional Apathy Scale (DAS), assessing Executive, Emotional and Initiation apathy subtypes, a one-dimensional apathy measure, depression measure, functional and cognitive screens. Apathy subtype awareness was determined through DAS informant/carer- and self-ratings discrepancy. Apathy profile comparison showed bvFTD patients had significantly higher Emotional apathy than AD patients (p < .01) and significantly higher apathy over all subtypes than PPA patients (p’s < .05). Additionally, bvFTD patients had significantly lower awareness for Emotional apathy (p < .01) when compared to AD and PPA patients. All patient groups had significant global apathy over all subtypes compared to controls. The emergent apathy profile for bvFTD seems to be Emotional apathy (indifference or emotional/affective neutrality), with lower self-awareness in this subtype. Further, lower self-awareness for Executive apathy (lack of motivation for planning, organisation or attention) differentiates bvFTD from PPA. Future research should investigate the cognitive and neural correlates as well as the practical impact of apathy subtypes.
Keywords / Materials (for Non-textual outputs)
- Alzheimer’s disease
- behavioural variant frontotemporal dementia
- primary progressive aphasia
- frontotemporal dementia