Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification

Yichuan Zhang, Alessia Gambardella, Muhammed Üçüncü, Jin Geng, Jessica Clavadetscher, Mark Bradley, Annamaria Lilienkampf

Research output: Contribution to journalArticlepeer-review


A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer–protein conjugates, while the tetrazine conjugation strategy allows myriad cargos to be attached and amplified.
Original languageEnglish
JournalChemical Communications
Early online date9 Oct 2020
Publication statusE-pub ahead of print - 9 Oct 2020

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