TY - JOUR
T1 - Multifunctional, histidine-tagged polymers: antibody conjugation and signal amplification
AU - Zhang, Yichuan
AU - Gambardella, Alessia
AU - Üçüncü, Muhammed
AU - Geng, Jin
AU - Clavadetscher, Jessica
AU - Bradley, Mark
AU - Lilienkampf, Annamaria
PY - 2020/10/9
Y1 - 2020/10/9
N2 - A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer–protein conjugates, while the tetrazine conjugation strategy allows myriad cargos to be attached and amplified.
AB - A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer–protein conjugates, while the tetrazine conjugation strategy allows myriad cargos to be attached and amplified.
U2 - 10.1039/D0CC04591H
DO - 10.1039/D0CC04591H
M3 - Article
SN - 1359-7345
JO - Chemical Communications
JF - Chemical Communications
ER -
