Multimodal, label-free nonlinear optical imaging for applications in biology and biomedical science: Multimodal, label-free nonlinear optical imaging

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Abstract

We have developed a multimodal optical platform for label-free imaging on the basis of nonlinear optical microscopy (NLO) for applications in biology and biomedical science. Three application areas have been chosen as examples: regenerative medicine, drug delivery monitoring and cancer diagnosis. Obtained data showed the potential of NLO microscopy for the following: (1) investigating the stem cell differentiation states prior their use in regenerative medicine and tissue repair, (2) tracking drug molecules in living cells and (3) detecting cancer by imaging biopsies ex vivo. The results of this study illustrate the potential to translate NLO microscopy from ex vivo to in vivo applications. Copyright (c) 2013 John Wiley & Sons, Ltd.
Original languageEnglish
Pages (from-to)1373-1378
Number of pages6
JournalJournal of Raman Spectroscopy
Volume44
Issue number10
Early online date1 Jun 2013
DOIs
Publication statusPublished - Oct 2013

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