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Abstract
Multiphase field models have emerged as an important computational tool for understanding biological tissue while resolving single-cell properties. While they have successfully reproduced many experimentally observed behaviors of living tissue, the theoretical underpinnings have not been fully explored. We show that a two-dimensional version of the model, which is commonly employed to study tissue monolayers, can be derived from a three-dimensional version in the presence of a substrate. We also show how viscous forces, which arise from friction between different cells, can be included in the model. Finally, we numerically simulate a tissue monolayer and find that intercellular friction tends to solidify the tissue.
Original language | English |
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Article number | 044403 |
Pages (from-to) | 1-15 |
Number of pages | 15 |
Journal | Physical Review E |
Volume | 110 |
Issue number | 4 |
DOIs | |
Publication status | Published - 17 Oct 2024 |
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Dive into the research topics of 'Multiphase field model of cells on a substrate: From three dimensional to two dimensional'. Together they form a unique fingerprint.Projects
- 1 Finished
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[LC]2: 'Living' Colloidal Liquid Crystals
Shendruk, T. (Principal Investigator)
1/08/20 → 31/05/25
Project: Research