Abstract / Description of output
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice(85%, P
Original language | English |
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Pages (from-to) | 1313-1327 |
Number of pages | 15 |
Journal | Endocrine-Related Cancer |
Volume | 16 |
Issue number | 4 |
DOIs | |
Publication status | Published - Dec 2009 |
Keywords / Materials (for Non-textual outputs)
- FRANCE
- MEN1 GENE
- INSULINOMA
- HYPERPARATHYROIDISM
- TISSUES
- CHROMOSOME-11
- IDENTIFICATION
- MUTATIONS
- CHROMOGRANIN-A
- MOUSE MODEL