Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia

Brian Harding, Manuel C. Lemos, Anita A. C. Reed, Gerard V. Walls, Jeshmi Jeyabalan, Michael R. Bowl, Hilda Tateossian, Nicky Sullivan, Tertius Hough, William D. Fraser, Olaf Ansorge, Michael T. Cheeseman, Rajesh V. Thakker*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice(85%, P

Original languageEnglish
Pages (from-to)1313-1327
Number of pages15
JournalEndocrine-Related Cancer
Volume16
Issue number4
DOIs
Publication statusPublished - Dec 2009

Keywords

  • FRANCE
  • MEN1 GENE
  • INSULINOMA
  • HYPERPARATHYROIDISM
  • TISSUES
  • CHROMOSOME-11
  • IDENTIFICATION
  • MUTATIONS
  • CHROMOGRANIN-A
  • MOUSE MODEL

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