Multiple marker mapping of quantitative trait loci in a cross between outbred wild boar and large white pigs

S A Knott, L Marklund, C S Haley, K Andersson, W Davies, H Ellegren, M Fredholm, I Hansson, B Hoyheim, K Lundström, M Moller, L Andersson

Research output: Contribution to journalArticlepeer-review

Abstract

A quantitative trait locus (QTL) analysis of growth and fatness data from a three generation pig experiment is presented. The population of 199 F2 animals was derived from a cross between wild boar and Large White pigs. Animals were typed for 240 markers spanning 23 Morgans of 18 autosomes and the X chromosome. A series of analyses are presented within a least squares framework. First, these identify chromosomes containing loci controlling trait variation and subsequently attempt to map QTLs to locations within chromosomes. This population gives evidence for a large QTL affecting back fat and another for abdominal fat segregating on chromosome 4. The best locations for these QTLs are within 4 cM of each other and, hence, this is likely to be a single QTL affecting both traits. The allele inherited from the wild boar causes an increase in fat deposition. A QTL for intestinal length was also located in the same region on chromosome 4 and could be the same QTL with pleiotropic effects. Significant effects, owing to multiple QTLs, for intestinal length were identified on chromosomes 3 and 5. A single QTL affecting growth rate to 30 kg was located on chromosome 13 such that the Large White allele increased early growth rate, another QTL on chromosome 10 affected growth rate from 30 to 70 kg and another on chromosome 4 affected growth rate to 70 kg.
Original languageEnglish
Pages (from-to)1069-80
Number of pages12
JournalGenetics
Volume149
Issue number2
Publication statusPublished - Jun 1998

Keywords

  • Animals
  • Chromosome Mapping
  • Confidence Intervals
  • Crosses, Genetic
  • Female
  • Genetic Linkage
  • Genetic Markers
  • Genetic Variation
  • Genomic Imprinting
  • Halothane
  • Heterozygote Detection
  • Least-Squares Analysis
  • Male
  • Models, Genetic
  • Quantitative Trait, Heritable
  • Swine

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