Multiple roles for the Wilms' tumour suppressor gene, WT1 in genitourinary development

A Schedl, N Hastie

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Wilms' tumour is a childhood kidney cancer, and a classic example of cancer arising through disrupted development (Armstrong et al., 1992). It is one of the most common solid paediatric malignancies, affecting one in 10000 children. The genetics of Wilms' tumour is complicated, with several different genes or chromosomal regions being implicated (Armstrong et al., 1992). However, the gene we know most about is the Wilms' tumour predisposition gene, WT1 (Bickmore et al., 1992; Bruening and Pelletier, 1996). It is now clear that mutations in this gene in humans can lead to abnormalities of the kidneys and gonads, as well as to the eponymous tumour. Also, as discussed below, WT1 is essential for kidney, testis and ovary development, as revealed in knockout mice.
Original languageEnglish
Pages (from-to)65-9
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume140
Issue number1-2
Publication statusPublished - 25 May 1998

Keywords / Materials (for Non-textual outputs)

  • Animals
  • DNA-Binding Proteins
  • Female
  • Gene Expression Regulation
  • Genes, Wilms Tumor
  • Genitalia
  • Gonadal Dysgenesis
  • Humans
  • Male
  • Mutation
  • Transcription Factors
  • Urinary Tract
  • WT1 Proteins
  • Wilms Tumor

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