Multiplexed optical pathogen detection with lab-on-a-chip devices

Holger Schulze, Gerard Giraud, Jason Crain, Till T. Bachmann

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Infectious diseases are still a main cause of human morbidity and mortality. Advanced diagnostics is considered to be a key driver to improve the respective therapeutic outcome. ne main factors influencing the impact of diagnostics include: assay speed, availability, information content, in-vitro diagnostics and cost, for which molecular assays are providing the most promising opportunities. Miniaturisation and integration of assay steps into lab-on-a-chip devices has been described as an appropriate way to speed up assay time and make assays available onsite at competitive costs. As meaningful assays for infectious diseases need to include a whole range of clinical relevant information about the pathogen, multiplexed functionatity is often required for which optical transduction is particularly welt suited. The aim of this review is to assess existing developments in this field and to give an outlook on future requirements and solutions.

Original languageEnglish
Pages (from-to)199-211
Number of pages13
JournalJournal of biophotonics
Volume2
Issue number4
DOIs
Publication statusPublished - Apr 2009

Keywords

  • infectious diseases
  • microTAS
  • in vitro diagnostics
  • point of care testing
  • REAL-TIME PCR
  • INTEGRATED MICROFLUIDIC DEVICE
  • FLUORESCENCE DETECTION SYSTEM
  • GENETIC-ANALYSIS MICROSYSTEMS
  • RESISTANT ESCHERICHIA-COLI
  • SINGLE-MOLECULE DETECTION
  • STEP DNA EXTRACTION
  • WAVE-GUIDES
  • CAPILLARY-ELECTROPHORESIS
  • SAMPLE PREPARATION

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