Multisite gynecologic endometrioid adenocarcinomas: Can mutation profiling be used to distinguish synchronous primary cancers from metastases?

Dominique Barnes, Nissreen Mohammad, Lien Hoang, Michael Anglesio, Robert L Hollis, Charlie Gourley, Heather C. Stuart, Mark S. Carey, Gavin C.e. Stuart

Research output: Contribution to journalArticlepeer-review

Abstract

It is well recognized that some patients with endometrioid gynecological cancers have tumors arising in multiple sites (ovary, endometrium, and endometriosis) at the time of diagnosis. Molecular analysis has helped discern whether these multisite cancers represent synchronous primary tumors or alternatively metastatic disease. We present a complex case of a patient with endometrioid carcinomas arising in multiple sites. We discuss the use of mutation profiling to discern clonality and highlight how this information may inform the clinical management of such cases.
Original languageEnglish
Article number101076
Pages (from-to)101076
JournalGynecologic Oncology Reports
Volume44
DOIs
Publication statusPublished - 14 Oct 2022

Keywords

  • Endometrioid carcinoma
  • Mutation analysis
  • Clonality
  • Gynecologic cancers

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