Multistep synthesis on SU-8: Combining microfabrication and solid-phase chemistry on a single material

Gabriel Cavalli, Shahanara Banu, Rohan T. Ranasinghe, Graham R. Broder, Hugo F. P. Martins, Cameron Neylon, Hywel Morgan, Mark Bradley, Peter L. Roach

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

SU-8 is an epoxy-novolac resin and a well-established negative photoresist for microfabrication and microengineering. The photopolymerized resist is an extremely highly crosslinked polymer showing outstanding chemical and physical robustness with residual surface epoxy groups amenable for chemical functionalization. In this paper we describe, for the first time, the preparation and surface modification of SU-8 particles shaped as microbars, the attachment of appropriate linkers, and the successful application of these particles to multistep solid-phase synthesis leading to oligonucleotides and peptides attached in an unambiguous manner to the support surface.

Original languageEnglish
Pages (from-to)462-472
Number of pages11
JournalJournal of combinatorial chemistry
Volume9
Issue number3
DOIs
Publication statusPublished - 2007

Keywords / Materials (for Non-textual outputs)

  • HIGH-ASPECT-RATIO
  • PEPTIDE-SYNTHESIS
  • CAPILLARY-ELECTROPHORESIS
  • PROTEASE INHIBITORS
  • MASS-SPECTROMETRY
  • ARCHIP EPOXY
  • PHOTORESIST
  • OLIGONUCLEOTIDES
  • IMMOBILIZATION
  • MEMS

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