Abstract
Murine gammaherpesvirus (MHV-68) causes an acute respiratory infection followed by a latent infection in B lymphocytes. In the first 2-3 weeks after infection mice develop a marked splenomegaly, where the spleen cell number increases by 2-3 fold. Cytofluorimetric analysis during splenomegaly revealed an increase in numbers of B lymphocytes and of both CD4+ and CD8+ T lymphocytes. The largest increase relative to uninfected spleens was in the CD8+ population. The number of latently infected cells in the spleen peaked at day 10 post-intraperitoneal infection, then declined to 1/10(6)-1/10(7) cells per spleen. Depletion of CD4+ T lymphocytes prevented the splenomegaly and greatly reduced the peak infective centre level, while having no effect on the long-term of latently infected cells. Given the similarity between MHV-68-induced splenomegaly and Epstein-Barr virus-induced infectious mononucleosis, these data highlight the usefulness of MHV-68 as a mouse model for the study of gammaherpesvirus immunology and pathobiology.
Original language | English |
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Pages (from-to) | 627-30 |
Number of pages | 4 |
Journal | Journal of General Virology |
Volume | 77 ( Pt 4) |
Publication status | Published - Apr 1996 |
Keywords / Materials (for Non-textual outputs)
- Animals
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Gammaherpesvirinae
- Herpesviridae Infections
- Lymphocyte Count
- Lymphocyte Depletion
- Mice
- Mice, Inbred BALB C
- Spleen
- Splenomegaly
- Virus Latency