TY - JOUR
T1 - Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults
AU - Böttcher, Adriana
AU - Zarucha, Alexis
AU - Köbe, Theresa
AU - Gaubert, Malo
AU - Höppner, Angela
AU - Altenstein, Slawek
AU - Bartels, Claudia
AU - Buerger, Katharina
AU - Dechent, Peter
AU - Dobisch, Laura
AU - Ewers, Michael
AU - Fliessbach, Klaus
AU - Freiesleben, Silka Dawn
AU - Frommann, Ingo
AU - Haynes, John Dylan
AU - Janowitz, Daniel
AU - Kilimann, Ingo
AU - Kleineidam, Luca
AU - Laske, Christoph
AU - Maier, Franziska
AU - Metzger, Coraline
AU - Munk, Matthias H J
AU - Perneczky, Robert
AU - Peters, Oliver
AU - Priller, Josef
AU - Rauchmann, Boris-Stephan
AU - Roy, Nina
AU - Scheffler, Klaus
AU - Schneider, Anja
AU - Spottke, Annika
AU - Teipel, Stefan J
AU - Wiltfang, Jens
AU - Wolfsgruber, Steffen
AU - Yakupov, Renat
AU - Düzel, Emrah
AU - Jessen, Frank
AU - Röske, Sandra
AU - Wagner, Michael
AU - Kempermann, Gerd
AU - Wirth, Miranka
N1 - Copyright © 2022 Böttcher, Zarucha, Köbe, Gaubert, Höppner, Altenstein, Bartels, Buerger, Dechent, Dobisch, Ewers, Fliessbach, Freiesleben, Frommann, Haynes, Janowitz, Kilimann, Kleineidam, Laske, Maier, Metzger, Munk, Perneczky, Peters, Priller, Rauchmann, Roy, Scheffler, Schneider, Spottke, Teipel, Wiltfang, Wolfsgruber, Yakupov, Düzel, Jessen, Röske, Wagner, Kempermann and Wirth.
PY - 2022/8/25
Y1 - 2022/8/25
N2 - Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer's disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults (OA) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Participants reporting having played a musical instrument across three life periods (
n = 70) were compared to controls without a history of musical instrument playing (
n = 70), well-matched for reserve proxies of education, intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion.
AB - Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer's disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults (OA) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Participants reporting having played a musical instrument across three life periods (
n = 70) were compared to controls without a history of musical instrument playing (
n = 70), well-matched for reserve proxies of education, intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion.
U2 - 10.3389/fpsyg.2022.945709
DO - 10.3389/fpsyg.2022.945709
M3 - Article
C2 - 36092026
SN - 1664-1078
VL - 13
SP - 945709
JO - Frontiers in Psychology
JF - Frontiers in Psychology
ER -