Mutant mice and neuroscience: Recommendations concerning genetic background

Alcino J. Silva; Elizabeth M. Simpson; Joseph S. Takahashi; Hans Peter Lipp; Shigetada Nakanishi; Jeanne M. Wehner; Karl P. Giese; Tim Tully; Ted Abel; Paul F. Chapman; Kevin Fox; Seth Grant; Shigeyoshi Itohara; Richard Lathe; Mark Mayford; James O. McNamara; Roger J. Morris; Marina Picciotto; John Roder; Hee Sup Shin; Paul A. Slesinger; Daniel R. Storm; Michael P. Stryker; Susumu Tonegawa; Yanyan Wang; David P. Wolfer

doi:10.1016/S0896-6273(00)80958-7

Mutant mice and neuroscience: Recommendations concerning genetic background

Alcino J. Silva, Elizabeth M. Simpson, Joseph S. Takahashi, Hans Peter Lipp, Shigetada Nakanishi, Jeanne M. Wehner, Karl P. Giese, Tim Tully, Ted Abel, Paul F. Chapman, Kevin Fox, Seth Grant, Shigeyoshi Itohara, Richard Lathe, Mark Mayford, James O. McNamara, Roger J. Morris, Marina Picciotto, John Roder, Hee Sup ShinPaul A. Slesinger, Daniel R. Storm, Michael P. Stryker, Susumu Tonegawa, Yanyan Wang, David P. Wolfer

Research output: Contribution to journal › Comment/debate › peer-review

Abstract / Description of output

Controlling genetic background during the construction and testing of mutants is complex. Here, we propose that the genetic background of the mutants should always be described in detail, and that any background used should be easily recreated from available stocks. We also propose that both transgenic and gene-targeted mice be generated and maintained in inbred genetic backgrounds (i.e., either 129/J and/or C57BL/6). We propose the study of F1 hybride mice whenever possible (50% C57BL/6 and 50% 129/J). It is important to standardize the genetic background of the mutants studied the facilitate the comparison of results between experiments and among laboratories.

Original language	English
Pages (from-to)	755-759
Number of pages	5
Journal	Neuron
Volume	19
Issue number	4
DOIs	https://doi.org/10.1016/S0896-6273(00)80958-7
Publication status	Published - 1997

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Silva, A. J., Simpson, E. M., Takahashi, J. S., Lipp, H. P., Nakanishi, S., Wehner, J. M., Giese, K. P., Tully, T., Abel, T., Chapman, P. F., Fox, K., Grant, S., Itohara, S., Lathe, R., Mayford, M., McNamara, J. O., Morris, R. J., Picciotto, M., Roder, J., ... Wolfer, D. P. (1997). Mutant mice and neuroscience: Recommendations concerning genetic background. Neuron, 19(4), 755-759. https://doi.org/10.1016/S0896-6273(00)80958-7

@article{926bd14fb3144d09ae92b11f86b76830,

title = "Mutant mice and neuroscience: Recommendations concerning genetic background",

abstract = "Controlling genetic background during the construction and testing of mutants is complex. Here, we propose that the genetic background of the mutants should always be described in detail, and that any background used should be easily recreated from available stocks. We also propose that both transgenic and gene-targeted mice be generated and maintained in inbred genetic backgrounds (i.e., either 129/J and/or C57BL/6). We propose the study of F1 hybride mice whenever possible (50% C57BL/6 and 50% 129/J). It is important to standardize the genetic background of the mutants studied the facilitate the comparison of results between experiments and among laboratories.",

author = "Silva, {Alcino J.} and Simpson, {Elizabeth M.} and Takahashi, {Joseph S.} and Lipp, {Hans Peter} and Shigetada Nakanishi and Wehner, {Jeanne M.} and Giese, {Karl P.} and Tim Tully and Ted Abel and Chapman, {Paul F.} and Kevin Fox and Seth Grant and Shigeyoshi Itohara and Richard Lathe and Mark Mayford and McNamara, {James O.} and Morris, {Roger J.} and Marina Picciotto and John Roder and Shin, {Hee Sup} and Slesinger, {Paul A.} and Storm, {Daniel R.} and Stryker, {Michael P.} and Susumu Tonegawa and Yanyan Wang and Wolfer, {David P.}",

year = "1997",

doi = "10.1016/S0896-6273(00)80958-7",

language = "English",

volume = "19",

pages = "755--759",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "4",

}

Silva, AJ, Simpson, EM, Takahashi, JS, Lipp, HP, Nakanishi, S, Wehner, JM, Giese, KP, Tully, T, Abel, T, Chapman, PF, Fox, K, Grant, S, Itohara, S, Lathe, R, Mayford, M, McNamara, JO, Morris, RJ, Picciotto, M, Roder, J, Shin, HS, Slesinger, PA, Storm, DR, Stryker, MP, Tonegawa, S, Wang, Y & Wolfer, DP 1997, 'Mutant mice and neuroscience: Recommendations concerning genetic background', Neuron, vol. 19, no. 4, pp. 755-759. https://doi.org/10.1016/S0896-6273(00)80958-7

TY - JOUR

T1 - Mutant mice and neuroscience

T2 - Recommendations concerning genetic background

AU - Silva, Alcino J.

AU - Simpson, Elizabeth M.

AU - Takahashi, Joseph S.

AU - Lipp, Hans Peter

AU - Nakanishi, Shigetada

AU - Wehner, Jeanne M.

AU - Giese, Karl P.

AU - Tully, Tim

AU - Abel, Ted

AU - Chapman, Paul F.

AU - Fox, Kevin

AU - Grant, Seth

AU - Itohara, Shigeyoshi

AU - Lathe, Richard

AU - Mayford, Mark

AU - McNamara, James O.

AU - Morris, Roger J.

AU - Picciotto, Marina

AU - Roder, John

AU - Shin, Hee Sup

AU - Slesinger, Paul A.

AU - Storm, Daniel R.

AU - Stryker, Michael P.

AU - Tonegawa, Susumu

AU - Wang, Yanyan

AU - Wolfer, David P.

PY - 1997

Y1 - 1997

N2 - Controlling genetic background during the construction and testing of mutants is complex. Here, we propose that the genetic background of the mutants should always be described in detail, and that any background used should be easily recreated from available stocks. We also propose that both transgenic and gene-targeted mice be generated and maintained in inbred genetic backgrounds (i.e., either 129/J and/or C57BL/6). We propose the study of F1 hybride mice whenever possible (50% C57BL/6 and 50% 129/J). It is important to standardize the genetic background of the mutants studied the facilitate the comparison of results between experiments and among laboratories.

AB - Controlling genetic background during the construction and testing of mutants is complex. Here, we propose that the genetic background of the mutants should always be described in detail, and that any background used should be easily recreated from available stocks. We also propose that both transgenic and gene-targeted mice be generated and maintained in inbred genetic backgrounds (i.e., either 129/J and/or C57BL/6). We propose the study of F1 hybride mice whenever possible (50% C57BL/6 and 50% 129/J). It is important to standardize the genetic background of the mutants studied the facilitate the comparison of results between experiments and among laboratories.

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DO - 10.1016/S0896-6273(00)80958-7

M3 - Comment/debate

AN - SCOPUS:0030777698

SN - 0896-6273

VL - 19

SP - 755

EP - 759

JO - Neuron

JF - Neuron

IS - 4

ER -

Mutant mice and neuroscience: Recommendations concerning genetic background

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