Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not in primary tumours

H Ozdağ, S J Batley, A Försti, N G Iyer, Y Daigo, J Boutell, M J Arends, B A J Ponder, T Kouzarides, C Caldas

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we screened the histone acetyltransferases CBP and PCAF for mutations in human epithelial cancer cell lines and primary tumours. We identified two CBP truncations (both in cell lines), seven PCAF missense variants and four CBP intronic microdeletions. These data suggest that neither gene is commonly inactivated in human epithelial cancers.
Original languageEnglish
Pages (from-to)1162-5
Number of pages4
JournalBritish Journal of Cancer
Volume87
Issue number10
DOIs
Publication statusPublished - 4 Nov 2002

Keywords

  • Acetyltransferases
  • Blotting, Western
  • CREB-Binding Protein
  • Cell Cycle Proteins
  • Exons
  • Histone Acetyltransferases
  • Humans
  • Introns
  • Mutation
  • Neoplasms, Glandular and Epithelial
  • Nuclear Proteins
  • Saccharomyces cerevisiae Proteins
  • Trans-Activators
  • Transcription Factors
  • Tumor Cells, Cultured
  • p300-CBP Transcription Factors

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