Mutational analysis of the Wolfram syndrome gene in two families with chromosome 4p-linked bipolar affective disorder

Kathryn Evans, D Lawson, T Meitinger, Douglas Blackwood, D J Porteous

Research output: Contribution to journalArticlepeer-review

Abstract

Bipolar affective disorder (BPAD) is a complex disease with a significant genetic component. Heterozygous carriers of Wolfram syndrome (WFS) are at increased risk of psychiatric illness. A gene for WFS (WFS1) has recently been cloned and mapped to chromosome 4p, in the general region we previously reported as showing linkage to BPAD. Here we present sequence analysis of the WFS1 coding sequence in five affected individuals from two chromosome 4p-linked families. This resulted in the identification of six polymorphisms, two of which are predicted to change the amino acid sequence of the WFS1 protein, however none of the changes segregated with disease status. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:158-160, 2000.
Original languageEnglish
Pages (from-to)158-60
Number of pages3
JournalThe American Journal of Medical Genetics - Part A (AJMG)
Volume96
Issue number2
DOIs
Publication statusPublished - 2000

Keywords / Materials (for Non-textual outputs)

  • Bipolar Disorder
  • Chromosomes, Human, Pair 4
  • DNA Mutational Analysis
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Heterozygote Detection
  • Humans
  • Membrane Proteins
  • Wolfram Syndrome

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