This article reviews the role of defective base excision repair, and MUTYH specifically, in colorectal cancer etiology and discusses the consequences of MUTYH gene defects, with particular emphasis on clinical relevance to colorectal polyposis, colorectal cancer risk, and appraising the risk of extra-colonic malignancy. Evidence guiding clinical practice, in terms of surveillance recommendations and options for surgical and other prophylactic interventions, is reviewed.
- Cell Differentiation: *physiology
- Cells, Cultured
- Embryonic Stem Cells: cytology: *physiology
- Hepatocytes: cytology: *physiology
- Mesoderm: cytology: *physiology
- Stromal Cells: cytology: *physiology
- Wnt Proteins: genetics: *metabolism