MUTYH-associated polyposis and colorectal cancer

M. G. Dunlop; S. M. Farrington

doi:10.1016/j.soc.2009.08.003

MUTYH-associated polyposis and colorectal cancer

Research output: Contribution to journal › Article › peer-review

Abstract

This article reviews the role of defective base excision repair, and MUTYH specifically, in colorectal cancer etiology and discusses the consequences of MUTYH gene defects, with particular emphasis on clinical relevance to colorectal polyposis, colorectal cancer risk, and appraising the risk of extra-colonic malignancy. Evidence guiding clinical practice, in terms of surveillance recommendations and options for surgical and other prophylactic interventions, is reviewed.

Original language	English
Pages (from-to)	599-610
Number of pages	12
Journal	Surgical oncology clinics of North America
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.soc.2009.08.003
Publication status	Published - Oct 2009

Keywords

Cell Differentiation: *physiology
Cells, Cultured
Embryonic Stem Cells: cytology: *physiology
Hepatocytes: cytology: *physiology
Humans
Mesoderm: cytology: *physiology
Stromal Cells: cytology: *physiology
Wnt Proteins: genetics: *metabolism

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10.1016/j.soc.2009.08.003

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title = "MUTYH-associated polyposis and colorectal cancer",

abstract = "This article reviews the role of defective base excision repair, and MUTYH specifically, in colorectal cancer etiology and discusses the consequences of MUTYH gene defects, with particular emphasis on clinical relevance to colorectal polyposis, colorectal cancer risk, and appraising the risk of extra-colonic malignancy. Evidence guiding clinical practice, in terms of surveillance recommendations and options for surgical and other prophylactic interventions, is reviewed.",

keywords = "Cell Differentiation: *physiology, Cells, Cultured, Embryonic Stem Cells: cytology: *physiology, Hepatocytes: cytology: *physiology, Humans, Mesoderm: cytology: *physiology, Stromal Cells: cytology: *physiology, Wnt Proteins: genetics: *metabolism",

author = "Dunlop, {M. G.} and Farrington, {S. M.}",

year = "2009",

month = oct,

doi = "10.1016/j.soc.2009.08.003",

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publisher = "W.B. Saunders Ltd",

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AU - Dunlop, M. G.

AU - Farrington, S. M.

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AB - This article reviews the role of defective base excision repair, and MUTYH specifically, in colorectal cancer etiology and discusses the consequences of MUTYH gene defects, with particular emphasis on clinical relevance to colorectal polyposis, colorectal cancer risk, and appraising the risk of extra-colonic malignancy. Evidence guiding clinical practice, in terms of surveillance recommendations and options for surgical and other prophylactic interventions, is reviewed.

KW - Cell Differentiation: physiology

KW - Cells, Cultured

KW - Embryonic Stem Cells: cytology: physiology

KW - Hepatocytes: cytology: physiology

KW - Humans

KW - Mesoderm: cytology: physiology

KW - Stromal Cells: cytology: physiology

KW - Wnt Proteins: genetics: metabolism

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U2 - 10.1016/j.soc.2009.08.003

DO - 10.1016/j.soc.2009.08.003

M3 - Article

VL - 18

SP - 599

EP - 610

JO - Surgical oncology clinics of North America

JF - Surgical oncology clinics of North America

SN - 1055-3207

IS - 4

ER -

MUTYH-associated polyposis and colorectal cancer

Abstract

Keywords

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