MUTYH-associated polyposis and colorectal cancer

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This article reviews the role of defective base excision repair, and MUTYH specifically, in colorectal cancer etiology and discusses the consequences of MUTYH gene defects, with particular emphasis on clinical relevance to colorectal polyposis, colorectal cancer risk, and appraising the risk of extra-colonic malignancy. Evidence guiding clinical practice, in terms of surveillance recommendations and options for surgical and other prophylactic interventions, is reviewed.
Original languageEnglish
Pages (from-to)599-610
Number of pages12
JournalSurgical oncology clinics of North America
Issue number4
Publication statusPublished - Oct 2009


  • Cell Differentiation: *physiology
  • Cells, Cultured
  • Embryonic Stem Cells: cytology: *physiology
  • Hepatocytes: cytology: *physiology
  • Humans
  • Mesoderm: cytology: *physiology
  • Stromal Cells: cytology: *physiology
  • Wnt Proteins: genetics: *metabolism


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