Mycobacterium leprae-induced demyelination: A model for early nerve degeneration

Anura Rambukkana

doi:10.1016/j.coi.2004.05.021

Mycobacterium leprae-induced demyelination: A model for early nerve degeneration

Anura Rambukkana^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.

Original language	English
Pages (from-to)	511-518
Number of pages	8
Journal	Current Opinion in Immunology
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/j.coi.2004.05.021
Publication status	Published - 1 Aug 2004

Keywords / Materials (for Non-textual outputs)

central nervous system
CNS
DRP2
dystroglycan-related protein 2
G
GBS
globular
Guillain-Barre syndrome
LCMV
lepromatous leprosy
LL
lymphocytic choriomeningitis virus
MS
multiple sclerosis
peripheral nervous system
PGL-1
phenolic glycolipid-1
PNS

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10.1016/j.coi.2004.05.021

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title = "Mycobacterium leprae-induced demyelination: A model for early nerve degeneration",

abstract = "The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.",

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author = "Anura Rambukkana",

year = "2004",

month = aug,

day = "1",

doi = "10.1016/j.coi.2004.05.021",

language = "English",

volume = "16",

pages = "511--518",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

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number = "4",

}

TY - JOUR

T1 - Mycobacterium leprae-induced demyelination

T2 - A model for early nerve degeneration

AU - Rambukkana, Anura

PY - 2004/8/1

Y1 - 2004/8/1

N2 - The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.

AB - The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.

KW - central nervous system

KW - CNS

KW - DRP2

KW - dystroglycan-related protein 2

KW - G

KW - GBS

KW - globular

KW - Guillain-Barre syndrome

KW - LCMV

KW - lepromatous leprosy

KW - LL

KW - lymphocytic choriomeningitis virus

KW - MS

KW - multiple sclerosis

KW - peripheral nervous system

KW - PGL-1

KW - phenolic glycolipid-1

KW - PNS

UR - http://www.scopus.com/inward/record.url?scp=3042814735&partnerID=8YFLogxK

U2 - 10.1016/j.coi.2004.05.021

DO - 10.1016/j.coi.2004.05.021

M3 - Review article

C2 - 15245748

AN - SCOPUS:3042814735

SN - 0952-7915

VL - 16

SP - 511

EP - 518

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 4

ER -

Mycobacterium leprae-induced demyelination: A model for early nerve degeneration

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Keywords / Materials (for Non-textual outputs)

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