Mycobacterium leprae-induced demyelination: A model for early nerve degeneration

Anura Rambukkana*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.

Original languageEnglish
Pages (from-to)511-518
Number of pages8
JournalCurrent Opinion in Immunology
Volume16
Issue number4
DOIs
Publication statusPublished - 1 Aug 2004

Keywords

  • central nervous system
  • CNS
  • DRP2
  • dystroglycan-related protein 2
  • G
  • GBS
  • globular
  • Guillain-Barre syndrome
  • LCMV
  • lepromatous leprosy
  • LL
  • lymphocytic choriomeningitis virus
  • MS
  • multiple sclerosis
  • peripheral nervous system
  • PGL-1
  • phenolic glycolipid-1
  • PNS

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