Myelin repair: the role of stem and precursor cells in multiple sclerosis: the role of stem and precursor cells in multiple sclerosis

Siddharthan Chandran*, David Hunt, Alexis Joannides, Chao Zhao, Alastair Compston, Robin J. M. Franklin

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Multiple sclerosis is the most common potential cause of neurological disability in young adults. The disease has two distinct clinical phases, each reflecting a dominant role for separate pathological processes: inflammation drives activity during the relapsing-remitting stage and axon degeneration represents the principal substrate of progressive disability. Recent advances in disease-modifying treatments target only the inflammatory process. They are ineffective in the progressive stage, leaving the science of disease progression unsolved. Here, the requirement is for strategies that promote remyelination and prevent axonal loss. Pathological and experimental studies suggest that these processes are tightly linked, and that remyelination or myelin repair will both restore structure and protect axons. This review considers the basic and clinical biology of remyelination and the potential contribution of stem and precursor cells to enhance and supplement spontaneous remyelination.

Original languageEnglish
Pages (from-to)171-183
Number of pages13
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume363
Issue number1489
DOIs
Publication statusPublished - 12 Jan 2008

Keywords

  • multiple sclerosis
  • stem cells
  • precursor cells
  • neural repair
  • myelin
  • axonal injury
  • CENTRAL-NERVOUS-SYSTEM
  • EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
  • OLFACTORY ENSHEATHING CELLS
  • NEURAL PROGENITOR CELLS
  • ADULT HUMAN BRAIN
  • SUBCORTICAL WHITE-MATTER
  • BONE-MARROW-CELLS
  • RAT SPINAL-CORD
  • MATURE OLIGODENDROCYTE APOPTOSIS
  • INCREASING LOCAL-LEVELS

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